Advances in epigenetic changes induced by pathogenic factors of oral diseases
Journal Title: 口腔疾病防治 - Year 2019, Vol 27, Issue 6
Abstract
The oral cavity is a complex and complete ecosystem. In addition to the microbial community, anatomical structure, temperature, humidity, pH, nutrient sources, proteases, and external factors all influence the ecosystem. Under normal circumstances, this ecosystem maintains a dynamic balance with the host. However, due to the large number of influencing factors, this dynamic balance is fragile. Abnormal changes in a certain factor can disrupt this balance and cause oral cavity disease. Increasing studies have confirmed the role of genetic factors in the etiology of oral diseases. With the understanding of the pathogenesis of oral diseases, the pathogenic factors induced by oral diseases have attracted more attention. This article reviews the key role of epigenetic changes induced by pathogenic factors, such as bacteria, viruses, and cytokines, in the pathogenesis of oral diseases and contributes to the development and application of related drugs.
Authors and Affiliations
REN Yushu, LIN Xiaoping
Keywords
Related Articles
- EP ID EP623825
- DOI 10.12016/j.issn.2096-1456.2019.06.012
- Views 164
- Downloads 0
IgG4-related Mikulicz disease: a case report and literature review
Objective To explore the etiology, clinical manifestations, diagnosis and treatment of IgG4-related Mikulicz disease and to provide a reference for clinical diagnosis and treatment. Methods Case data from a patient with...
Finite element analysis of torque control efficiency of a homemade four-curved auxiliary arch for anterior teeth
Objective To analyze the initial displacement of the upper central incisor and stress distribution of periodontal ligament under different torque values of upper incisors under the action of a four-curved auxiliary arch...
Distribution of oral Streptococcus mutans and its correlation with dental caries in children of Bortala Mongolian Autonomous Prefecture
Objective To study the detection rate of Streptococcus mutans in oral cavities of 3-5-year-old Han, Uygur and Mongolian children in Bortala Mongolian Autonomous Prefecture, and the correlation between genotype and dental...
Establishment and stress analysis of buccal-occlusal-lingual inlay finite element model of mandibular first molar
Objective To observe the stress distribution according to a model of the bucco-occluso-lingual (BOL) inlay of mandibular first molar after restoration to provide a basis for the clinical treatment of cracked tooth with B...
The management of dental fear symptoms in children in a coparticipation model
Objective To explore the impact of procedural behavior management on children with dental fear (DF) using the interactive mode of coparticipative doctor-patient interactions.Methods Ninety-eight children with dental fear...