Advances in traditional Chinese medicine for liver disease therapy in 2020
Journal Title: Traditional Medicine Research - Year 2021, Vol 6, Issue 3
Abstract
Liver diseases are gradually becoming a serious threat to human health worldwide. Although a number of medications have been introduced for the prophylaxis, diagnosis, and treatment of liver diseases, several limitations and challenges remain. Traditional Chinese medicine is frequently used to treat liver diseases and well known to protect hepatocytes and inhibit inflammation, oxidative stress, and fibrosis. However, given the complex composition of traditional Chinese medicine, clarifying the mechanisms behind its curative and protective effects is difficult. In this review, research progress on traditional Chinese medicine for the treatment of liver diseases in 2020 is summarized on the basis of the literature available in the PubMed database. Herbal extracts derived from traditional Chinese medicine, including flavonoids, polysaccharides, saponins, and alkaloids, and Chinese medicinal formulas, such as the classic decoctions Chaihu Shugan powder, Linggui Zhugan decoction, and Huanglian Jiedu decoction, have shown promising therapeutic efficacy in liver disease treatment. We summarized the findings of several studies on the active ingredients of traditional Chinese herbs used for liver disease treatment in 2020, focusing mainly on their ability to confer antiviral effects to treat hepatitis, regulate antioxidant levels and apoptosis to treat liver injury, inhibit inflammation and improve dysfunctions in amino acids and energy metabolism to treat alcoholic liver disease, reduce hepatic lipid deposition to treat nonalcoholic fatty liver disease, promote activated hepatic stellate cells to treat liver fibrosis, inhibit the proliferation or promote the apoptosis of liver cancer cells to treat hepatocellular carcinoma, and improve bile acid metabolism to treat cholestasis.
Authors and Affiliations
Lu Yang, Jia-Bao Liao, An-Qi Liu, Xi Chen, Fei Qu, Huan-Tian Cui, Jing Miao
Keywords
Related Articles
- EP ID EP693638
- DOI 10.12032/TMR20210316225
- Views 127
- Downloads 0
Three-step acupuncture and cupping therapy: an effective approach to treat cervicogenic headache
As early as 1983, Sjaastad proposed the concept of cervicogenic headache (CH) in the World Headache Conference, that is, the pain from upper cervical joints and muscles can be referred to the head. CH is a group of syndr...
Marine natural products with anti-inflammation effects
The ocean possesses a complex setting with high pressure, high salinity, oligotrophy, low temperature and weak illumination conditions. To survive and evolve in such harsh surroundings, marine organisms metabolize a seri...
Quantitation of phytochemical constituents of Fumaria vaillantii L. with different extract methods
Objective: The genus fumaria includes more than 40 species in the world. The aim of this study was to quantify the phytochemical constituents of Fumaria vaillantii L. aerial parts and compare the different methods of ext...
Artificial tiger bone powder for improving the quality of life in elderly patients with fracture
Objective: To investigate the application of artificial tiger bone powder on fracture healing time, wrist functional recovery and quality of life (QOL) in elderly patients with distal radius fracture. Methods: The study...
The present treatment and mechanism progress of arsenic trioxide in hematological malignancies
This paper reviewed the development history of arsenic trioxide (ATO), and summarized its mechanisms and clinical application in the treatment of hematologic malignancies. ATO can induce tumor cell apoptosis, tumor cell...