Adverse drug reactions of antiepileptic agents among pediatric patients at tertiary care teaching hospital of Gujarat- a cross-sectional study
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2018, Vol 7, Issue 2
Abstract
Background and Aim Epilepsy is one of the most common neurological disorders characterized by recurrent episodic paroxysmal involuntary clinical events associated with abnormal electrical activity from the neurons. Antiepileptic treatment in pediatric age group should be aimed to control seizures associated with the lowest possible occurrence of adverse effects, thus allowing the child to become an active member of the community. Present study was performed with an aim to evaluate the adverse drug reactions (ADRs) caused by the anti-epileptic drugs Among Pediatric Patients of tertiary care teaching hospital of Gujarat. Material and Methods The present cross-sectional study was conducted at the epilepsy clinic of Department of Paediatrics, Tertiary Care teaching hospital of Gujarat, on patients diagnosed to have epilepsy July 2014 to October 2014. Hundred Paediatric patients of either gender diagnosed to had epilepsy and taking treatment from pediatric epilepsy clinic OPD, Tertiary Care teaching hospital of Gujarat. Patient’s detailed medical history, drug reports, demographic data, type of seizures, the anti-epileptic drugs prescribed and the adverse drug reactions (ADRs) reported by the patients were recorded in a pre-structured data entry form. Results Out of 100. GTCS was found to be the most common (55%) form of epilepsy among pediatric patients and Carbamazepine was the most commonly prescribed (41%) AED followed by sodium valproate (38%).24 patients suffered from ADRs of antiepileptic drugs. Out of which 7 patients suffered from drowsiness and suspected drug for this ADR were clobazam, levetiracetam and carbamazepine. Six patients suffered from irritability and suspected drugs for this ADR were clobazam, carbamazepine. Conclusion Total 24 patients suffered from ADRs of antiepileptic drugs. Drowsiness was most commonly observed ADR and suspected drugs for this ADR were clobazam, levetiracetam and carbamazepine.
Authors and Affiliations
Hirenkumar H Dave
Keywords
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