Aerosol Delivery Enhances Percutaneous Permeability of Epidermal Growth Factor and Thioredoxin
Journal Title: Journal of Clinical and Investigative Dermatology - Year 2015, Vol 4, Issue 1
Abstract
To evaluate the effect of a nano-spray instrument, we examined the transcutaneous permeability of human recombinant hioredoxin (rhTRX) and human recombinant epidermal growth factor (rhEGF). Distribution of rhTRX and rhEGF in skin issues was studied by immunohistochemical analyses after their application. At least 1 μg/ml rhEGF was distributed in the epidermis after application using the nano-spray instrument. Permeability of rhEGF decreased if the spraying time was horter or the spraying distance was longer. Sprayed rhTRX was distributed more densely in the epidermis, and could strongly uppressed irritant contact dermatitis induced by croton oil, compared with the painted rhTRX group. These data suggest that erosol delivery is a safe and effective method of enhancement of drug permeation into skin, and could be used to improve the ffects of drugs.
Authors and Affiliations
Atsushi Fukunaga
Keywords
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- EP ID EP204011
- DOI 10.13188/2373-1044
- Views 98
- Downloads 0
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