Aetiology, Diagnosis and Clinical Characteristics of Nephrocalcinosis
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 3
Abstract
ABSTRACT Introduction: Nephrocalcinosis (NC) is the increased deposition of calcium in the renal parenchyma due to different aetiologies. Aim: The present study aimed to investigate the aetiology of NC and its effect on renal function and growth in children. Materials and Methods: In the present study, 25 children diagnosed with NC between 1999 and 2016 were retrospectively analysed. Relevant demographic, clinical and laboratory data were extracted from patients’ records. Results: The median (range) age at diagnosis was 9 (3-84) months. The leading cause of NC was distal Renal Tubular Acidosis (dRTA) in 16 (64%), followed by Idiopathic Hypercalciuria (IH) in 2 (8%) children. Clinical manifestations were failure to thrive in 8 (32%), polyuria and polydipsia in 5 (20%), haematuria and renal colic in 2 (8%), urinary tract infection in 7 (28%) and in 3 (12%) cases, NC was found accidentally during routine checkup. Chronic renal insufficiency developed in two patients with dRTA and in one with hyperoxaluria. The degree of NC worsened in 3 (23%) patients, remained the same in 7 (54%) and improved in 3 (23%) patients. However, the effect of nephrocalcinosis grade change on renal function and growth was not significant. Conclusion: It is not the degree of NC rather the underlying cause and the age at diagnosis that affects the growth and renal function of children.
Authors and Affiliations
Lidvana Spahiu, Arbnore Batalli Këpuska, Vlora Ismaili Jaha, Besart Merovci, Haki Jashari
Keywords
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- EP ID EP514325
- DOI 10.7860/JCDR/2018/32270.11317
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