Age associated oxidative damage in RBC and serum of humans
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: To evaluate the level of lipid-protein damage and antioxidant status in red blood corpuscle (RBC) and serum of healthy individuals to correlate between oxidative damage with the aging process. Methods: Twenty healthy individuals of each age group (11-20; 21-30; 31-40; 41-50; and 51-60 years old) were selected randomly. Blood samples were drawn by medical practitioner and serum was separated and RBC was isolated from blood samples. Malondialdehyde (MDA), protein carbonyls (PC) level were evaluated to determine the lipid and protein damage in RBC and serum. superoxide dismutase (SOD), catalase (CAT), glutathione and glutathione dependent enzymes were estimated to evaluate the antioxidant status in RBC and serum. Results: Increased MDA and PC levels strongly supported the increased oxidative damage in elderly subject than young subjects. The results indicated that, balance of oxidant and antioxidant systems in RBC and serum shifts in favor of accelerated oxidative damage during aging. Conclusions: Oxidative stress in RBC and serum may particular interest in aging and may play important role in immunosenescence.
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