Aggressive orbital Burkitt’s lymphoma with rapid onset proptosis
Journal Title: Medpulse International Journal of Ophthalmology - Year 2017, Vol 4, Issue 3
Abstract
Burkitt’s lymphoma is rare B cell monoclonal malignant lymphoma with short doubling time (less than 3 days) occurring due to deregulation of c-myc oncogene. Most Burkitt’s lymphomas (80% to 90%) carry a translocation of the proto-oncogene c-myc from chromosome 8 to the immunoglobulin heavy chain region on chromosome 14 [t(8;14)]. In 10% to 20% of cases the c-myc gene is translocated to the kappa light chain loci on chromosome 2 [t(8;2)] or to the lambda light chain on chromosome 22 [t(8;22)]. Translocation leads to over-expression of the c-myc oncogene. Increased incidence is found in AIDS patients. In the sporadic form of the disease that occurs worldwide in non-endemic areas, mostly in developed countries, patients present with an abdominal mass that frequently involves the ileocecum in the bowel, whereas ocular or orbital involvement is rare.
Authors and Affiliations
Jayashri Thorat, Ranjana Bindu, Sujata Chahande, Smita Harne
Keywords
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