Airway Remodeling in the Asthma Model: Is there Standardization in this Evaluation?
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 15, Issue 1
Abstract
Asthma is a chronic inflammatory disease characterized by obstruction of airflow causing respiratory difficulties at various intensities. Airways inflammation has an impor-tant role in the pathophysiology of asthma. The inflammatory process in the airways pro-motes significant changes in the respiratory structures called airway remodeling, which represents a late and permanent response to tissue injury. This review aimed emphasize the importance of histological evaluation of airway remodeling in the asthma experimen-tal model. There are several methods of histopathological analysis available today, but the implementation of a standardized methodology would help in the damages caused by the allergens and future assessments of possible therapies used to treat the disease.Asthma is a chronic inflammatory disease characterized by obstruction of airflow causing respiratory difficulties at various intensities [1]. It represents a major cause of physical disability, affecting 300 million people worldwide [2]. Airways inflammation has an important role in the pathophysiology of asthma, which is characterized mainly by the TH2 type immune response. The inflammatory process in the airways of individuals with asthma promotes significant changes in the respiratory structures, induced by repeated lesions and repairs [3]. This review aimed emphasize the importance of histological evaluation of airway remodeling in the asthma experimental model.
Authors and Affiliations
Lidiane Maria Boldrini Leite, Pedro Vicente Michelotto Jr, Sérgio Adriane Bezerra de Moura, Paulo Roberto Slud Brofman
Keywords
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- EP ID EP591747
- DOI 10.26717/BJSTR.2019.15.002655
- Views 174
- Downloads 0
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