Albumin and IgG Removal by Cellulose Biosorbents
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 11
Abstract
Abstract: Proteomic analysis is a great and effective biomarker discovery tool that is being used to discover and identify various diseases biomarkers. The complexity of the plasma content exceeds the existing methods to determine lower abundance proteins that may prove to be informative biomarkers. The aim of this study was to investigate the removal efficiency of albumin and IgG (immunoglobulin G) by cellulose biosorbents in batch wise at room temperature. Polysaccharide based cellulose biosorbents were prepared and stabilized by solvent remove/solvent evaporation method in chitosan media. 2% chitosan amount, 1400 rpm stirring rate, 40oC solvent evaporation temperature were determined as optimal conditions in our previous study for polysaccharide based cellulose biosorbents. The prepared spherical biosorbents were then studied for albumin and IgG removal by cellulose biosorbents. 976,6 mg albumin/g polymer and 209 mg IgG/g capturing capacity was obtained with cellulose biosorbents. Keywords:Cellulose, Biosorbent, Albumin, IgG, Bioaffinity, Proteomic.
Authors and Affiliations
Aydan Gülsu, Fatma Ayhan
Keywords
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