Alteration of Corneal Structure in Patients with Diabetes Mellitus
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 8
Abstract
Objective: To determine the alteration in corneal characteristics such as endothelial cell density, mean cell area, coefficient of variation in cell size, hexagonality percentage and central corneal thickness in diabetic patients by comparing with a non diabetic group in a tertiary care hospital in South India Methods: A cross sectional study was done including 190 diabetic patients and 190 non diabetic subjects in the age group of 40-70 years enrolled over a period of 1 year. Demographic data was collected and specular microscopy and pachymetry was done for all the subjects. The corneal parameters were compared in the 2 groups using independent samples t test. Results: The mean age in the diabetic group was 57.91 and non diabetic group was 56.09. The mean values of mean cell area (437.17±134.32 and 394.11±143.68) coefficient of variation in cell size (28.02±9.94 and 22.68±6.09) were significantly higher in diabetic group compared to the non diabetic group. Hexagonality percentage was significantly lower in the diabetic group (55.46±19.65) compared to non diabetic group (75.94±6.48). Among the diabetic population, duration of diabetes had significant correlation with central corneal thickness (r=+0.190) and HbA1c levels had significant negative correlation with endothelial cell density and hexagonality (r=-0.318 and r=-0.239 respectively). Conclusions: Endothelial cell morphology was found to be altered in patients with diabetes compared to non diabetic subjects which was associated with duration of disease and glycemic control in diabetic patients. This may have implications in the careful selection and intraoperative precautions in patients undergoing intraocular procedures.
Authors and Affiliations
Chitra Raghavan
Keywords
Related Articles
- EP ID EP529829
- DOI -
- Views 72
- Downloads 0
Prevalence of Body Dysmorphic Disorder in Patients Attending Dermatology clinic in Saudi Arabia/Qassim Region
Objective: To assess the prevalence of Body Dysmorphic Disorder in Patients attending a dermatology clinic in Saudi Arabia/ Qassim Region. Methods: Cross sectional study conducted among 363 patients aged 15 years old and...
Is Enhanced Recovery after Gastric Surgery Feasible for Gastric Cancer in Our Setup
Background: Enhanced recovery after surgery (ERAS) is a new concept of perioperative patient care that focuses on the minimization of impact of surgery on patients homeostasis. The concept is being routinely practised in...
Endobronchial Carcinoid Tumours – A Case Series and review of Literature
Bronchial carcinoid tumors are neuroendocrine neoplasms. The spectrum can range from low-grade typical carcinoids to more aggressive atypical carcinoids. Most bronchial carcinoids are located in central airways, hence cl...
Comet Assay and Urinary 8-OHdG: A Marker of Oxidative Stress in Oral Cancer with Puducherry Population
Background: Establishment of early prediction of oral cancer is important. We evaluated both lymphocyte DNA damage by Single cell gel electrophoresis (SCGE) and non-invasive urinary 8-hydroxy-2- deoxyguanosine (8-OHdG) b...
Pattern of Childhood Epilepsies in a Tertiary Health Facility in Nnewi, South-East Nigeria
Background: Childhood epilepsy is one of the commonest chronic neurologic disorders affecting children in developing countries. Objective: This study is aimed to determine the pattern of childhood epilepsies in a Nigeria...