Alteration of serum dehydroepiandrosterone and its sulfated derivative in hypothyroidism
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction Dysfunction of thyroid gland are among the most common disease of endocrine glands which affect a considerable portion of the population Thyroid abnormalities are accompanied by changes in various intermediary metabolism which results in body weight alteration insulin resistance lipid profile and various biochemical parameters Changes in dehydroepiandrosterone DHEA and its sulfated metabolite Dehydroepiandrosterone sulfate have been reported in patients with thyroid hypofunction but the evidence is controversial and not yet established The present study planned to explore the association between thyroid function with DHEA and DHEAS levels in hypothyroid patientsMaterials and Methods An observational case control study was conducted in OPD patients of Rajshree Medical College of Rohilkhand region RMRI Bareilly70 newly diagnosed hypothyroid patients were selected and all the biochemical parameters plasma glucose thyroid profile DHEA and DHEAS were compared with 70 age and sex matched healthy euthyroid controls Statistical analysis was done using SPSS 220 versionResults We found that serum DHEA and DHEAS levels were significantly reduced in hypothyroid patients as compared to control pConclusion The present study demonstrated that hypothyroidism is associated with significantly low levels of DHEA and DHEAS concentration Alteration of these sterols in hypothyroidism clearly indicates that thyroid hormone may stimulate the synthesis of these androgen precursors though more elaborate study with increased sample size may provide more insightsKeywords Hypothyroidism Dehydroepiandrosterone Dehydroepiandrosterone sulfate
Authors and Affiliations
Ranadip Mukherjee, Sumeru Samanta, Nityanand Upadhyay
Keywords
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- EP ID EP475448
- DOI 10.18231/2394-6377.2018.0134
- Views 97
- Downloads 0
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