Alterations in hippocampal calcium-binding neurons induced by stress models of depression: a preliminary assessment.
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 6
Abstract
In this study, the neuropathological changes induced by chronic unpredictable stress (CUS) and chronic mild stress (CMS) in calbindin D-28K (CB) and parvalbumin (PV) immunoreactive neurons in the rat hippocampus were demonstrated. We used immunohistochemical techniques to quantify the numerical density and morphological changes of PV immunoreactive and CB immunoreactive neurons in the dentate gyrus (DG) and the CA1 and CA3 regions of the hippocampus. We also assessed cell proliferation (Ki-67) and apoptotic processes (active caspase-3) in the DG. We found a significant decrease (16.6% for CUS and 13.3% for CMS) in the numerical density of granule cells (GC), alterations in the CB immunoreactive cells of the GC in the DG and an impairment of mossy fiber CB immunolabelling in the CA3. These changes were not accompanied by a decrease in Ki-67 labeling or the level of capsase-3 in the DG. These data indicate a stress-induced reduction of calcium binding neuron parameters, which may be related to the behavioral paradigms exhibited in these models.
Authors and Affiliations
Barbara Nowak, Monika Zadrożna, Grażyna Ossowska, Magdalena Sowa-Kućma, Piotr Gruca, Mariusz Papp, Małgorzata Dybała, Andrzej Pilc, Gabriel Nowak
Keywords
Related Articles
- EP ID EP85281
- DOI -
- Views 100
- Downloads 0
Neuroprotective effect of carvedilol against aluminium induced toxicity: possible behavioral and biochemical alterations in rats.
Aluminium, is a trace element available in the Earth's crust naturally and has a toxic potential for humans. It has been suggested as a contributing factor in the pathogenesis of Alzheimer's disease. β-Adrenoceptor block...
Anti-inflammatory plasma cytokines in children and adolescents with migraine headaches.
Studies have shown fluctuations of cytokine levels in patients with migraine headaches; however, further studies are needed to verify these results. Our previous studies suggest increased levels of pro-inflammatory cytok...
Cytoprotective effects of CSTMP, a novel stilbene derivative, against H(2)O(2)-induced oxidative stress in human endothelial cells.
A novel stilbene derivative, (E)-2-(2-chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP), was designed and synthesized based on the pharmacophores of tetramethylpyrazine (TMP) and resveratrol (RES). In the present study, we i...
Constitutive activity of beta-adrenergic receptors in C6 glioma cells.
Alprenolol and propranolol (0.001-10 muM) significantly and concentration-dependently inhibited both isoprenaline-driven and basal (non-stimulated) cyclic adenosine monophosphate (cAMP) accumulation in the rat C6 glioma...
Involvement of adenosine receptors in dizocilpine-induced motor activity in mice.
The effect of adenosine receptor ligands on dizocilpine-induced locomotion was studied in mice. Dizocilpine-induced hyperactivity (0.1 mg/kg ip) in mice was antagonized by all adenosine receptor agonists: CPA - A(1) rece...