Amaryl®М SR: a New Release Form, New Possibilities for The Patients
Journal Title: Міжнародний ендокринологічний журнал - Year 2015, Vol 5, Issue 69
Abstract
The review deals with a new form of oral antidiabetic drugs with a fixed dose — the combination of sustained-release metformin and glimepiride. Amaryl®M SR (2/500 mg) — a new dosage form, which provides a rapid release of glimepiride, and then the slow release of metformin from multipolymer hydrophilic matrix independently of pH. Based on the research of therapeutic efficacy and bioavailability, it is shown that this form is characterized by an optimal pharmacokinetics of metformin and glimepiride, does not increase the incidence of hypoglycemia, may be administered once a day, and is associated with less severe gastrointestinal side effects, as well as has more pronounced compliance. Application of Amaryl®M SR creates new possibilities for patients with type 2 diabetes mellitus in terms of optimizing glycemic control and quality of life.
Authors and Affiliations
V. V. Роltorak, M. Yu. Gorshunska, N. S. Krasova
Keywords
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