AMELIORATIVE EFFECTS OF DIFFERENT PARTS OF GEMOR (NOTHAPHOEBE CORIACEA) ON CADMIUM INDUCED GLUCOSE METABOLISM ALTERATION IN VITRO
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: The present study was undertaken to investigate the ameliorative effect of the bark and leaves of Nothaphoebe coriacea (gemor) on Cadmium (Cd) induced glucose metabolism alteration in liver homogenate in vitro.Methods: Glucose metabolism alteration in liver homogenate was induced by the administration of Cadmium Sulphate (CdSO4) at a dose 3 mg/l. Ameliorative effect of the leaves and bark extracts was determined by assessing the concentration of glycogen, glucose and Methylglyoxal (MG). Dubois hydrolytic method was used for liver glycogen and glucose concentration estimation. Modified Dinitro Phenyl Hydrazine (DNPH) method was used for MG concentration estimation.Results: The results of this present studies showed that treatment with CdSO4 significantly decreased the levels of glycogen and MG concentration, and increased the level of glucose in liver homogenate compared to control. The aqueous extracts of bark and leaves of gemor significantly increased the levels of glycogen and MG concentration, and decreased the level of glucose in liver homogenate compared to control. The aqueous extracts of the bark of gemor in comparison with CdSO4 treatment group showed the significant effect to maintain the glycogen, glucose, and MG concentration in liver homogenate. However, when compared to the aqueous extracts of leaves of gemor the result was not significant. The results suggest aqueous extracts of the bark of gemor was more effective to prevent the glucose metabolism alteration induced by CdSO4 than the aqueous extracts of leaves of gemor.Conclusion: The present study demonstrated Cd could induced the glucose metabolism alteration in liver homogenate, and the aqueous extracts of bark and leaves of gemor showed the ameliorative effect to prevent this alteration. In addition, the bark was more effective than leaves of gemor to prevent the glucose metabolism alteration induced by Cd.Â
Authors and Affiliations
Eko Suhartono, Iskandar . , Purwanto Budi Santosa
Keywords
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