AMELIORATIVE EFFECTS OF MAGNOLIA BARK EXTRACT CONSUMPTION IN ELDERLY MICE CARDIAC DYSFUNCTION
Journal Title: Kocatepe Medical Journal - Year 2024, Vol 25, Issue 2
Abstract
OBJECTIVE: It has been shown that to use Magnolia tree bark extract as supplement nutrient provided an anti-oxidative effect in various mammalian tissues and organs by several studies, however, there is no data associated with its cardioprotective role in physiological aging-related heart disorders. Therefore, here, we aimed to investigate whether Magnolia tree bark extract, containing magnolol and honokiol components (MAHO-C), has positive effects on heart dysfunction from aged mice (24-month-old). MATERIAL AND METHODS: One group of aged mice (male BALB/c) was fed with a standard mouse chow plus MAHO-C (400 mg/kg/day, for 12 weeks with intragastrical), while the second group of aged mice was fed only with the standard chow. Following the end of the supplementation period, in situ electrocardiogram (ECG) measurements and biochemical analyzes associated oxidative stress and antioxidant system parameters of the isolated heart tissues from all mice were performed. RESULTS: When compared to the nonsupplemented aged mice, the analysis performed in the ECGs of the aged mice supplemented with MAHO-C showed statistically significant decreases in the durations of P-waves, QRS-complexes, and QT-intervals as well as increases in the heart rates. The biochemical analysis of the heart tissues showed that the activity of arylesterase and total antioxidant levels in the heart tissues of the aged mice supplemented with MAHO-C were significantly high compared to those of untreated aged mice. In addition, when compared to the nonsupplemented group, there were significant decreases in the activity of the mitochondrial enzyme succinate dehydrogenase, one of source of reactive oxygen species (ROS) and the total oxidant level with a significant increase in the ratio of ATP to ADP in the heart samples of the aged mice supplemented with MAHO-C. CONCLUSIONS: Overall, our data suggest that MAHO-C supplementation provides significant positive effects on both electrical and biochemical properties of the insufficiently functioning hearts from the physiological aged mice, particularly through affecting the antioxidant defense system and mitochondria.
Authors and Affiliations
Simge ÜNAY, İrem AKTAY, Belma TURAN
Keywords
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- EP ID EP740639
- DOI https://doi.org/10.18229/kocatepetip.1302307
- Views 45
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