Ameliorative Effects of Sesame Seed Oil Against Penconazole-Induced Testicular Toxicity and Endocrine Disruption in Male Rats
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 14, Issue 1
Abstract
The current study investigated the protective effect of sesame seed oil (SSO) against testicular damage and endocrine disruption induced by the oral intoxication with penconazole (PENZ), a commonly used systemic triazole fungicide, in adult male Wistar rats. Subchronic oral exposure to two different doses of PENZ significantly reduced fertility indices, serum luteinizing hormone, follicle stimulating hormone, triiodothyronine and thyroxine levels, and by contrast a significant increase was recorded in serum estradiol and testosterone levels. Furthermore, PENZ significantly depleted testicular vitamins (A, C and E) level. On the other hand, administration of SSO prior to PENZ intoxication ameliorated most of the fertility indices and minimized PENZ-induced adverse effects on serum sexual, reproductive and thyroid hormones, compared to PENZ-treated animals. Histological data confirmed the biochemical findings. In conclusion, supplementation of SSO might be beneficial against the endocrine-disrupting potential and testicular toxicity induced by PENZ in adult male rats. Penconazole (PENZ), a fungicide that belongs to the triazole class, is commonly used in agriculture, horticulture and forestry industries for the control of powdery mildew [1]. It stops fungal growth by inhibiting lanosterol-14-demethylase (CYP51), which is required for ergosterol biosynthesis [2]. As a result of its in-depth utilization as an agrochemical, PENZ residues remain on treated crops, which may affect the environmental safety and human health [3,4]. Being refractory to degradation because of its long mean halflife value (117 days), PENZ is susceptible to accumulate in soils [5]. Sesame seed oil (SSO), derived from the seeds of Sesamum indicum L., is an important edible oil rich in fatty acids, including linoleic (39 to 59%), oleic (35% to 54%), palmitic acid (10%) and stearic acid (5%), tocopherols, phytosterols and lignans, such as sesamin, sesaminol, sesamolin, and a small amount of sesamol, minerals including, iron, calcium, magnesium, zinc and copper, as well as [6,7]. The major lignan of sesame seed is sesamin that possesses a myriad of beneficial effects on human health [8-14]. Following exposure to agricultural pesticides, several studies demonstrated a reduction in sperm count and semen quality, considering the testis as a sensitive indicator of male reproductive toxicity [15,16]. Exposure to PENZ had been previously reported to cause structural and functional testicular toxicity in male rats [1]. Therefore, the current study was undertaken to verify PENZinduced toxic effects on rat testes and endocrine disrupting potential and the probable protective effect of SSO supplementation.
Authors and Affiliations
Ibrahim H Borai, Azza A Atef, Afaf A El Kashoury, Rania A Mohamed, Mahmoud M Said
Keywords
Related Articles
- EP ID EP593827
- DOI 10.26717/BJSTR.2019.14.002486
- Views 184
- Downloads 0
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