An Analysis of CNS Tumors in Squash Preparations with Histological Correlation
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Background: Squash cytologyis now a well establishedand universally accepted techniquein diagnosing a wide range of CNS lesions and is currently employed for both therapeutic and prognostic reasons. Aims and Objectives: This study was conducted with an aim to correlate squash smears with histopathology and to compare statistical data employing sensitivity, specificity and diagnostic accuracy of squash cytology. The study also aims to find the pitfalls and limitations of Squash technique. Materials and Methods: An analysis of 100 brain tumour was done by squash preparation with histopathological correlationto evaluate the usefulness of the procedure. Crush Cytology smears were stained by Rapid H&E. Histopathology smears were made from formalin fixed tissues sent separately and stained with H&E. Results: Out of 100 cases, complete correlation with the final diagnosis was achieved in82%. Diagnostic accuracy increased to 92% when cases of partial correlation due tograding deviations were included. The sensitivity and specificity of neuroepithelialtumours were 86.6% and 98.18% respectively. The positive predictive value was 97.5% and negative predictive value was 90%. 10% partial correlation defect was not significant to affect the management of patient. Conclusion: The study shows it is possible to make correct diagnosis by squash preparation in 92% of the cases. The diagnostic yield is very high when the technique is combined withhistopathology. Itmaybe used as auseful adjunct to conventional histopathology.
Authors and Affiliations
Dr. Teleflo Boopathy, Dr. V. Karthika
Keywords
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