An anaplastic cardiac large cell lymphoma: A case report and analysis of cardiac involvement in newly diagnosed non-Hodgkin’s lymphoma from the Czech Lymphoma Study Group (CLSG) database
Journal Title: Journal of Cancer Research & Therapy - Year 2017, Vol 5, Issue 10
Abstract
We report a rare case of anaplastic large cell ALK+ lymphoma (ALCL) with initial asymptomatic cardiac involvement. A 59-year-old male with infiltration of the right ventricular wall underwent standard combined chemotherapy (CHOP) and achieved remission without significant cardiac impairment. Additionally, we report the actual incidence of cardiac lymphoma in newly diagnosed non-Hodgkin Lymphomas (NHLs). In total, 16 patients with cardiac lymphoma were found (0.1% NHLs) in the Czech Lymphoma Study Group database. DLBCL was the most frequent histology subtype (50%), and ALCL was identified in 12.5% of cases. At initial diagnosis, the median age was 55.5 (range 21-74) years and 59% were men. None of the 16 patients with cardiac involvement had isolated heart lymphoma. The response to first-line therapy was 79% in 14/16 evaluable patients. The median progression-free survival and overall survival were nearly the same – approximately 3.5 years (range; 0.05-16.7ys), while the median follow up was 4 years.
Authors and Affiliations
Lobello Cosimo, Janikova Andrea, Kren Leos, Hermanová Markéta, Sprlakova-Puková Andrea, Krejci Jan, Pospisilova Sarka, Hamouzova Michaela, Belada David, Prochazka Vit, Duras Juraj, Mocikova Heidi, Trneny Marek
Keywords
Related Articles
- EP ID EP539309
- DOI 10.14312/2052-4994.2017-13
- Views 65
- Downloads 0
The use of lacZ-transduced tumor cells enhances the sensitivity of micrometastasis detection: A comparative study of gemcitabine treatment efficacy in the mouse LM8 osteosarcoma cell model
In osteosarcoma patients as well as in preclinical osteosarcoma animal models post-therapy detection of residual disease and of metastases in particular remains a great challenge. The therapeutic efficacy is often overes...
HTLV-1 can be involved in acceleration of different nonhematological cancers
In the past two decades it has been found that viral proteins might contribute to activation of numerous pathways involved in different types of cancer. Human T-lymphotropic virus 1 (HTLV-1), well known as a cause of T-c...
Synergistic antineoplastic action of 5-aza-2'deoxycytidine (decitabine) in combination with different inhibitors of enhancer of zeste homolog 2 (EZH2) on human lung carcinoma cells
Patients with metastatic lung cancer have a very poor prognosis indicating an urgent need to develop more effective chemotherapy. Aberrant promoter DNA methylation can result in the epigenetic silencing of tumor suppress...
Development of novel approach to diagnostic imaging of lung cancer with 18F-Nifene PET/CT using A/J Mice treated with NNK
Development of novel methods of early diagnosis of lung cancer is one of the major tasks of contemporary clinical and experimental oncology. In this study, we utilized the tobacco nitrosamine 4-(methylnitrosamino)-1-(3-p...
Clinical study of the treatment of multiple brain metastases from adenocarcinoma of the lung by simultaneous integrated boost intensity-modulated radiotherapy
Objective: To investigate the effects of simultaneous integrated boost intensity-modulated radiotherapy (SIB) and sequential boost conformal radiotherapy (CRT) in treatment of multiple brain metastases from lung adenocar...