AN ASSESSMENT OF ANGIOGENESIS IN FIBROCYSTIC BREAST DISEASE AND INVASIVE BREAST CARCINOMA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 78
Abstract
BACKGROUND Fibrocystic disease (FCD) of breast is one of the most common benign condition of the breast, and breast cancer is the second most common cancer in women. Ductal hyperplasia is a frequent constituent of fibrocystic change. Moderate to florid hyperplasia is at slightly increased risk of breast carcinoma. In recent years, evidences suggest that quantification of angiogenesis by immune staining for endothelial cell markers may be a useful prognostic predictor. MATERIALS AND METHODS 30 cases of FCD of breast and 30 cases of invasive breast carcinoma were immunohistochemically stained for CD34 and microvessel density was assessed in 3 highly vascularised spots and the average was taken. RESULTS In present study, the association between ductal epithelial hyperplasia in FCD and grade of microvessel density was statistically significant (p value< 0.05). The correlation between histological grade of IDC- NOS Type and grade of microvessel density was statistically significant (p value <0.05). CONCLUSION The extent of angiogenesis in FCD with hyperplasia and invasive ductal carcinoma is an important prognostic factor.
Authors and Affiliations
Duraisamy Raman, Sudha Boj, Dhanalakshmi Arumugam, Lalitha Chidambaram
Keywords
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- EP ID EP268047
- DOI 10.14260/jemds/2017/1206
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