An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence
Journal Title: Polish Journal of Surgery - Year 2017, Vol 89, Issue 5
Abstract
The aim of the study: We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. Material and methods: Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism. Conclusion: The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.<br/><br/>
Authors and Affiliations
Anna Walczak, Karolina Przybyłowska-Sygut, Andrzej Sygut, Adrianna Cieślak, Michał Mik, Łukasz Dziki, Adam Dziki, Ireneusz Majsterek
Keywords
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- EP ID EP227292
- DOI 10.5604/01.3001.0010.5246
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