AN EVALUATION OF STRESS OXIDATIVE AND SERUM ELECTROLYTES IN FEMALE HYPOTHYROID PATIENTS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 3
Abstract
The present study evaluates the effects of hypothyroidism states on stress oxidative in female patients before treatment. 24 cases of overt hypothyroidism and 24 age matched controls were chosen. Blood samples were collected from them and T3, T4 and TSH levels were measured. Also, MDA, GSH, Sodium, Potassium and Chloride levels in blood was measured. The levels of serum MDA and sodium were significantly increased (p <0.01 and p <0.001) in hypothyroidism patients as compared to the control subjects. The results showed a highly significant decrease (p <0.01) in the levels of GSH in all patients with thyroid dysfunction as compared to control. Mean serum potassium and chloride levels are non-significantly changed in hypothyroid patients when compared to females control. In hypothyroidism patients, there was a significant negative correlation (r = 0.962; P < 0.05) between the levels of GSH with concomitant increase in MDA levels. There was a no significant correlation between serum MDA values and serum TSH and electrolytes levels. The results of this study reveal the importance of monitoring the levels of those stress oxidative parameters and serum electrolytes levels in thyroid dysfunction patients before therapy, especially when the disease is more severe.
Authors and Affiliations
Derouiche Samir
Keywords
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