An Evaluation of the Efficacy of Clonazepam in Patients with Burning Mouth Syndrome in comparison with Lycopene: A Double-Blinded clinical Study
Journal Title: International Journal of Medical Science and Diagnosis Research (IJMSDR) - Year 2018, Vol 2, Issue 5
Abstract
Burning mouth syndrome (BMS) as defined by the International Association for the Study of Pain is the burning pain in the tongue or other oral mucous mem¬brane that are associated with normal signs and laboratory fin¬dings lasting at least 4 to 6 months. This study was designed to evaluate the clinical efficacy of clonazepam in comparison with lycopene in treating patients with burning mouth syndrome (BMS). Thirty patients were randomized into two groups equally. Group-1 was administered with Clonazepam at a dose of 0.25mg before bed for 1 week, with escalation of the dose by no more than 0.25 mg each week to a maximum dose not greater than 3.0 mg per day in 3 divided doses. Group-2 was administered with lycopene 4 mg twice daily for a period of 8 weeks. The patients were evaluated by the severity of burning sensations using a 10-point visual analog scale (VAS: 0-10; 0=no burning sensation and 10= worst possible burning sensation) and follow-up visits at 2, 4, 6 and 8 weeks to assess the score. The subjects comprised of 10 males and 20 females with an average age years. The results of this study showed that there was reduction in burning sensation significantly at subsequent follow up visits at 2nd, 4th, 6th and 8th weeks in both the groups but these changes were much more pronounced in patients receiving Clonazepam compared to patients receiving Lycopene Clonazepam has been found effective on pain in patients with burning mouth syndrome and there has been no major side effects that would severely restrict its application. Key words: Burning mouth syndrome, Clonazepam, Lycopene
Authors and Affiliations
Bashir Ahmad Wani
Keywords
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