AN EVALUATION OF THE WOUND HEALING AND ANTI-MICROBIAL PROPERTY OF THE TINCTURE OF LANTANA CAMARA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: Lantana camaraL (L. c) has been known for its anti-bacterial activity since quite some time in its various extracts and pharmacological preparations. In view of this, we plan to study and compare the wound healing property of tincture of L. cin surgically induced wound in animal models with tincture of iodine (I2).Methods: An herbal tincture was developed from stems of L. cin concentrations of 20%, 40%, alcohol in tincture was followed as mentioned in IP, tested against tincture I2 in same aged different groups of rats under incision and excision models, also with commonly wound infecting bacteria like S. aureus, E. coli, E. fecalis, P. aeruginosa[a1] . Wounds were induced surgically under anaesthesia. Excised rats were observed for wound contraction and epithelialisation. On 7th day, incised rats were subjected to wound dehiscence test. Tissue biopsy took on day 5, 14 and21 for histopathological studies.Results: Both test groups were found statistically significant against standard with P<0.05 and with mean epithelialisation day value 11±1.02 in the excision model and P<0.05 between the groups in incision model depicting 20% tincture as better with a mean value of 366.67±47.2. Histologically 40% tincture was found non-inferior against standard. Tincture was active against mentioned microbes in various dilutions.Conclusion: Tincture L. c was non-inferior to iodine. Further studies with concentrated extracts of L. cmay reveal its accelerated healing and better anti-microbial competency so that it can be developed for clinical practice.Â
Authors and Affiliations
Vinay Kumar, Adarsh Preet Kaur, Uma V. K. , Ravi Kumar, Vandana K. E. , Veena Nayak
Keywords
Related Articles
- EP ID EP578829
- DOI -
- Views 91
- Downloads 0
EFFECT OFSALIX TETRASPERMAROXBUGH ON FRUCTOSE INDUCED HYPERTENSION IN RATS
Objective: The present study was designed to evaluate the effect of the ethanolic and aqueous extract of Salix tetrasperma Roxburgh on blood pressure by fructose induced hypertensive rats.Methods: The Salix tetrasperma R...
DEVELOPMENT OF VALIDATED STABILITY INDICATING METHOD BY RP-HPLC FOR SIMULTANEOUS ESTIMATION OF MEROPENEM AND VABORBACTAM IN BULK AND PHARMACEUTICAL FORMULATION
Objective: To develop a simple, rapid, precise and reproducible liquid chromatographic method for the estimation meropenem (MEP) and vaborbactam (VAB) in bulk and pharmaceutical formulation and study of the stability of...
EPILEPSY AND ORAL HORMONAL CONTRACEPTION-INDIAN PERSPECTIVE
There are about 50 million people with epilepsy in the world and a quarter of them are in the reproductive age group. India alone contributes to 10% of this fig. Because of the advances in therapeutic drugs, the women af...
ANTIMICROBIAL ACTIVITY OF SYZYGIUM CALOPHYLLIFOLIUM WALP. LEAF EXTRACT
Objective: To evaluate the antimicrobial activity of methanol extract of Syzygium calophyllifolium Walp. leaf against the gram-negative bacteria, namely, Escherichia coli, Klebsiella pneumonia, Salmonella typhi, Proteus...
EMERGING TRENDS IN PATIENT COUNSELLING: CURRENT SCENARIO
Objective: To evaluate the impact of patient counselling in terms of knowledge, attitudes and practices (KAP) outcomes among retail and hospital pharmacist in Satara and Sanagli district.Methods: A cross-sectional survey...