An exploration on cytotoxicity induced by tobacco products and Cyto-protective effects of certain plant extracts
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2018, Vol 10, Issue 7
Abstract
Cytotoxic effect of tobacco both in vivo and in vitro is confirmed by a wealth of scientific evidences available in literature. It is established that smokeless tobacco related tissue damage is related to reactive oxygen species production in oral cells, peritoneal macrophages, hepatic mitochondria and microsomes. In the present study, it is explored to compare the cytotoxic effects of three different tobacco samples and cyto-protective effects of three different plant extracts. Cyto-toxicity induced by tobacco samples andcyto-protective effects of plant extracts, when analysed, a reduction in % cell viability of oral epithelial cells after incubating with different tobacco extract was noted in a concentration dependent manner. Viability noted with tobacco -1 exposure was 73-52 % with increasing concentration, with tobacco -2 was 75 to 32% and with tobacco-3 was 52 to 23%. Simultaneous treatment with plant extracts along with tobacco samples resulted in reduction in cytotoxic effect reflected as increase in % viability than tobacco treatment alone, indicating the cyto-protective effect of plant extracts, but not to the level of untreated controls.
Authors and Affiliations
Maji Jose, Vengal Ipe Varghese, Varsha Jayakar, Vinayak Lokapur, Srinivasa, K. , Pratap, G.K. and Manjula Shantaram
Keywords
Related Articles
- EP ID EP403548
- DOI -
- Views 119
- Downloads 0
Denture Stability In Compromised Mandibular Residual Ridge With Neutral Zone Technique
One of the most common problems faced by mandibular complete denture patients is loose and unstable denture because of severely resorbed mandibular edentulous ridge. Prosthodontic rehabilitation of such patients with res...
Significance of plasma fibrinogen levels in ischemic stroke
Background: The pathogenic factors in stroke like atherosclerosis and thrombosis are the same as for myocardial infraction in the latter disease, significant increase in plasma fibrinogen level has been detected, which h...
Relationship between psychological well-being and age amongst malaysian graduates
The aim of this study was to examine whether there are significant relationship between age and psychological well-being components among graduate students. Psychological well-being is measured using the Scales of Psycho...
Ayurvedic management of sthoulya (obesity)
Ayurveda is one of the most ancient medical science among the world. It describes the conceptual study of different disease with reference to its own principles and approaches. According, to the Ayurveda ‘sthoulya’ is de...
A retrospective study on the occurrence and presentation of juvenile nasopharyngeal angiofibroma
Juvenile Nasopharyngeal Angiofibroma (JNA) is a rare breed of tumour found in adolescent males and there is a paucity of Indian studies on this subject. This is a retrospective observational study of JNA patients who pre...