An Observat ional Cross Sectional Study Of Seru m Anti - Mull erian Hormone In PCOS Infertile Women
Journal Title: International Journal of Scientific Research and Management - Year 2016, Vol 4, Issue 6
Abstract
OBJECTIVE: To evaluate the role of serum Anti - Mullerian Hormone in PCOS infertile women. METHOD: A total of 64 Polycystic ovary syndrome infertile women of 18 - 35 years age, according to Rotterdam Criteria (2003) were obser ved for role of serum Anti - Mullerian Hormone in PCOS infertile women. Serum levels of LH, FSH, testosterone, fasting insulin and AMH were measured in the early follicular phase (day 3 – 4) of natural cycle or progestin - induced withdrawal bleeding (in PCOS); together with TVS for detection of the number of small follicles (<10 mm) and calculation of ovarian volume. RESULTS: Serum AMH was significantly higher in the PCOS infertile women. 61 patients (95.3 percent) have serum AMH level >10ng/ml.59 patients (92. 2 percent) have number of follicles >12 (size <10mm) and higher ovarian volume. Serum Testosterone level >70 pg/dl in 27 patients (42.2 percent), LH/FSH ratio >2 in 38 patients (59.4 percent),34 (53.1 percent) patients have insulin resistance. Acne in 53(8 2.8 percent),Hirsutism in 42 (65.6 percent), Acanthosis nigricans in 8 (12.5 percent) patients, irregular menstrual cycle & oligo or amenorrhoea in 58 (90.6 percent) patients and BMI >25kg/m 2 in 41(64 percent) patients. CONCLUSION: Serum AMH is a good marker of Ovarian reserve. Serum AMH level two or three times the normal amount, is a good indicator of PCOS and infertility. It can be used as an alternative diagnostic criteria for PCOS patients and may be used as a marker for th e extent or severity of the disease in PCOS infertile female. AMH positively correlate to LH, LH/FSH, and number of follicles <10mm and ovarian volume . No correlation between AMH and age, BMI and fasting insulin level in PCOS infertile women.
Authors and Affiliations
Meena Veena
Keywords
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