An observative study of comparison of efficacy and tolerability between atenolol and combination of amolodopine with atenolol in the maintence therapy of hypertension in a tertiary care hospital
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 4
Abstract
Background Hypertension is the most common cardiovascular disease. The prevalence of hypertension increases with advancing age. The beta receptor antagonists provide effective therapy for all grades of hypertension. Compared with other classes of antihypertensive agents, there is a greater frequency of achieving blood pressure control with Ca2+ channel blockers as monotherapy. Because of paucity of published reports in the Indian literature regarding the pattern of use, efficacy, safety, tolerability of comparison of therapy of atenolol and combination of amolodopine and atenolol, the present study was taken up. Objectives To study the comparison of efficacy, safety and tolerability of atenolol and the combination of amolodopine and atenolol in achieving blood pressure control. Materials and methods 100 properly selected subjects with hypertension were included for the present study. The medication were used empirically as monotherapy or combination, OD or BID in a continuation manner. Blood pressure was measured at the baseline and daily afterwards for one month. The data collected was analyzed statistically using descriptive statistics. Tolerability and patient compliance for the prescribed medications were also assessed during the follow up visits. Results Blood pressure is maintained at the baseline level in both the study subjects. Fluctuations in baseline blood pressure were seen more in atenolol compare to combination therapy. Few non-serious adverse effects were noted in both the subjects, but more in combination therapy .The patient compliance for the prescribed medications was excellent.Interpretation and conclusion Hypertension can be more effectively treated by combination therapy than monotherapy of atenolol. But frequency of adverse effects is also more in combination therapy compare to monotherapy.
Authors and Affiliations
Dr. Wasif S
Keywords
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