AN OVERVIEW OF HELICOBACTER PYLORI INFECTIONS WITH SPECIAL REFERENCE TO PATHOGENESIS AND MECHANISM OF COLONIZATION
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 3
Abstract
Helicobacter pylori is the major causative agent of gastrointestinal diseases. The bacterial pathogen, H. pylori has co-evolved with humans and colonize about 50% of the human population, which however is largely asymptomatic, nevertheless H. pylori plays a major role in the long term interaction in humans considerably increase the risk for peptic ulcer disease, non cardiac gastric adenocarcinoma, chronic gastritis, peptic ulcer, gastric mucosa-associated lymphoid tissue lymphoma, Gastroesophageal reflux disease (GERD) and gastric cancer, H. pylori express a spectrum of virulence factors that deregulate host intracellular signaling pathways. In addition to bacterial determinants, numerous host and environmental factors increase the risk of gastric carcinogenesis. Due to their startle rate of drug resistance, eradication and control of H. pylori remains a global challenge. Triple therapy consisting of proton pump inhibitor, clarithromycin and either amoxicillin or metronidazole is commonly recommended standardization for treatment of H. pylori infection. This review discusses about the pathogenesis of H. pylori and the mechanisms it uses to promote persistent colonization of the gastric mucosa, with a focus on recent insights into the role of the virulence factors vaculating associated gene A (VacA), cytotoxin associated gene (CagA), BabA and also describe the H. pylori treatment.
Authors and Affiliations
Dr. N. Prabhusaran
Keywords
Related Articles
- EP ID EP654508
- DOI -
- Views 206
- Downloads 0
STUDY OF LIPID PROFILE IN CHRONIC SMOKERS ATTENDING SHADAN HOSPITAL-"TRASH THE ASH"
Smoking is one of the most potent and prevalent addictive habits, influencing behavior of human beings. There is a dose response relationship between number of cigarettes smoked per day and cardiovascular morbidity and m...
PREVALENCE OF HBSAG AND ANTI-HBC AMONG BLOOD DONORS AT THE NATIONAL BLOOD TRANSFUSION AND RESEARCH CENTER, SANA'A, YEMEN
Background: Substantial percentage of HBV cases were reported among our population. Blood transfusion represent major rout transmission of Hepatitis B virus. The recent situation in Yemen increase the demand of blood and...
A COMPARATIVE CLINICAL EVALUATION OF SOME AYURVEDIC DRUGS IN THE TREATMENT OF INFECTIVE HEPATITIS (KAMALA)
Recent WHO data indicates hepatitis now along with malaria as the fourth most common cause of death from infectious diseases in the world. Among the infectious hepatitis most common are Hepatitis A, B, C, D, E & G are th...
RECENT APPLICATION OF SOLVENT FREE GREEN SYNTHESIS OF SCHIFF’S BASES AND IT’S DERIVATIVES: A REVIEW
The Chemistry has wide scope for Carbon-Nitrogen bond forming reactions and upgrade from traditional towards modern synthetic and mutidisciplinary methods. The preferred interesting topic in chemistry that may benefit fr...
CLINICAL FOLLOW UP OF AESTHETIC INLAYS AND ONLAYS: SYSTEMATIC LITERATURE REVIEW
Aim: to analyze factors affecting success and failure of indirect bonded partial restorations (IBPR) include inlays, onlays and other partial crowns through a systematic review based on in vivo studies. Materials and Met...