AN OVERVIEW OF NSAIDS USED IN ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY AND PREVENTION GASTROINTESTINAL DAMAGE

Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 8

Abstract

Nonsteroidal anti-inflammatory agents/analgesics (NSAIDs) are a class of drugs that provide analgesic, antipyretic (fever-reducing) and in higher doses anti-inflammatory effects. The term "nonsteroidal" distinguishes these drugs from steroids, which among a broad range of other effects, have a similar eicosanoid-depressing, antiinflammatory action. As analgesics, NSAIDs are unusual in that they are non narcotic. Nonsteroidal antiinflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, antiinflammatory, and antipyretic actions may be beneficial, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. The most prominent members of this group of drugs are aspirin, ibuprofen, and naproxen. All of the drugs are available over the counter in most countries. NSAIDs are usually indicated for the treatment of acute or chronic conditions where pain and inflammation are present. In 2001, NSAIDs accounted for 70,000,000 prescriptions and 30 billion over-the-counter doses sold annually in the United States. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. This paper also provides the information on different preventive measures prescribed to minimize such adverse effects and analyses the new suggested strategies for development of novel drugs to maintain the anti-inflammatory functions of NSAIDs along with effective gastrointestinal protection.

Authors and Affiliations

Satya Prakash Singh*| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Satish Kumar Sharma| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Lalit Singh| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Sandhya Goyal| Department of Pharmaceutics, ISF College of Pharmacy, Ferozepur Road, Ghal Kalan, Moga, Punjab, India., Jineetkumar B. Gawad| Department of Pharmaceutical Chemistry, St. John Institute of Pharmacy & Research, Palghar (East), Thane, Maharashtra, India.

Keywords

Related Articles

Androgenetic alopecia and its remedies - a review

Androgenetic alopecia commonly referred to as male and female pattern balding is the slow progressive loss of head hair in a discrete pattern, sometimes to the level of baldness. Androgenetic alopecia and alopecia areata...

COMPARISON OF ERYTHROPOIETIN AND DARBEPOETIN IN CHRONIC KIDNEY DISEASE PATIENTS IN A TERTIARY CARE HOSPITAL

Chronic kidney disease (CKD), is a progressive loss of kidney function over several months to years and cause complications like anaemia. Erythropoiesis stimulating agents (ESAs) such as erythropoietin and darbepoetin a...

Transdermal drug delivery system: - a review on transdermal patch

The main advantage of Transdermal drug delivery system is to bypass the first pass metabolism, avertance of the risk and annoyance of intravenous therapy and of the varied conditions of absorption, like pH changes, gastr...

PRESENT STATUS OF PHARMACY EDUCATION AND FUTURE PROSPECTS AND CHALLENGE OF PHARMACY PRACTICE IN BANGLADESH

Pharmacy is a multi-disciplinary subject composed of all aspects of drugs including its manufacturing, synthesis, quality control and quality assurance, marketing, handling, safety matters, patients care, invention, and...

ETHOSOMES: A NOVEL APPROACH IN TRANSDERMAL DELIVERY OF THE DRUGS

Skin acts as a major target as well as a principal barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corne...

Download PDF file
  • EP ID EP1445
  • DOI -
  • Views 487
  • Downloads 28

How To Cite

Satya Prakash Singh*, Satish Kumar Sharma, Lalit Singh, Sandhya Goyal, Jineetkumar B. Gawad (2013). AN OVERVIEW OF NSAIDS USED IN ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY AND PREVENTION GASTROINTESTINAL DAMAGE. Journal of Drug Discovery and Therapeutics, 1(8), 41-51. https://europub.co.uk./articles/-A-1445