AN OVERVIEW OF RECOMBINANT VACCINE TECHNOLOGY, ADJUVANTS AND VACCINE DELIVERY METHODS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 11
Abstract
Development of an effective vaccine is of paramount important in disease prevention and control. As such, recombinant technology can serve as a gateway for the development of safe and effective vaccines that can be delivered effectively with an appropriate adjuvant. Therefore, this paper aimed to review the role of recombinant vaccine technology, new adjuvants and the challenge of vaccine delivery. Related peer-reviewed journal article searches were conducted using a subscribed database at the Universiti Putra Malaysia library, involving areas of Health Sciences and Medicine via Medline, SCOPUS and Google Scholar. New generation vaccines include highly purified synthetic or recombinant antigens that stimulate effective cell-mediated immune and mucosal immunity. In order to enhance their efficacy, a number of adjuvants are used. Efforts have also been made to explore the usage of non-invasive routes of administration, devices and equipment for optimized antigen and immune-potentiator delivery of the immune system. Recombinant vaccine technology is rapid, compared to the traditional method of vaccine development and does not require the handling of live viruses. It is, therefore, a promising technology for developing a future vaccine to curb emerging and re-emerging viral infections that may be life-threatening or teratogenic.
Authors and Affiliations
Shuaibu Abdullahi Hudu, Saadatu Haruna Shinkafi, Shuaibu Umar
Keywords
Related Articles
- EP ID EP575873
- DOI 10.22159/ijpps.2016v8i11.14311
- Views 78
- Downloads 0
TERMINALIA CHEBULA: AN EPHEMERAL GLANCE
Herbal drugs represent a major allocation of all the recognized systems of health in the world. Also, the medicinal plants have been regarded as valuable and cheap sources of various phytoconstituents which are used exte...
INDUSTRIALIZATION OF MEDROXY PROGESTERONE ACETATE IN PROLONGED PARENTAL SUSPENSION (PART I)
Objective: Medroxy progesterone acetate (MPA) is structurally related to progesterone it is given by mouth or by intramuscular (IM) as a contraceptive in an aqueous suspension injection. It was reported that the MPA susp...
VARIOUS FORMULATION VARIABLES EFFECTING FLOATATION BEHAVIOUR OF SINGLE UNIT GASTRORETENTIVE CAPSULES OF OFLOXACIN
Objective: Objective of the present study was to prepare simple single unit gastro-retentive capsules of ofloxacin with the aim to have the gastric retention of the system for longer periods of time (12h) and to study th...
A PROSPECTIVE INTERVENTIONAL STUDY OF KNOWLEDGE, ATTITUDE AND PRACTICE (KAP) TOWARDS TUBERCULOSIS AMONG PATIENTS WITH KOCH’S DISEASE
ABSTRACTObjective: To evaluate the knowledge, attitude and practice (KAP) of tuberculosis patients and to provide structured patient education through patient counselling on disease, drugs and lifestyle modifications in...
ISOLATION AND CHARACTERIZATION OF POTENTIAL PROBIOTICS FROM FERMENTED RAGI (ELEUSINE CORACANA)
Objective: The aim of this study was to isolate, characterize and identify the potential lactic acid bacteria from fermented ragi millet (Eleusine coracana).Methods: A total of 177 isolates were isolated from the ferment...