Analgesic effect of methanolic extract of Vetiveria zizanoides in wistar rats
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 2
Abstract
Introduction: Vetiveria zizanoides is used as a traditional medicine for a number of conditions, but there is lack of scientific data regarding its analgesic action.Aim: to study the analgesic action of methanolic extract of Vetiveria zizanoides (VZ) on animal models of analgesiaMethods: The animals were divided in to four groups (n=6). The groups received gum acacia, tramadol, VZ 300mg/kg and VZ 500 mg/kg orally. The analgesic effect of the plant extract was tested using hot plate and tail flick models.Results: VZ500 mg/kg produced a significant analgesic action in both the models of analgesia which was comparable to that of tramadol. VZ 300mg/kg produced significant analgesic action only hot plate model.Conclusion: The present study suggests the central analgesic action of methanolic extract of Vetiveria zizanoides. Further studies are required to confirm its analgesic action
Authors and Affiliations
Bharti Chogtu Magazine| Department of Pharmacology, Kasturba Medical College, Manipal, Manipal University, Karnataka, India, Veena Nayak*| Department of Pharmacology, Kasturba Medical College, Manipal, Manipal University, Karnataka, India, Pradeep AN| Department of Pharmacology, Kasturba Medical College, Manipal, Manipal University, Karnataka, India
Keywords
Related Articles
- EP ID EP1470
- DOI -
- Views 485
- Downloads 26
COMPARISON OF LABORATORY METHODS FOR THE DIAGNOSIS OF URINARY TRACT INFECTION
Introduction: Urinary Tract Infection (UTI) is most frequent bacterial infection.Conventional urine culture is widely used for its diagnosis. This method is time consuming, expensive and patients are often treated before...
PHARMACEUTICAL TASTE MASKING TECHNOLOGIES OF BITTER DRUGS: A CONCISE REVIEW
Taste refers to a perception arising from the stimulation of taste buds present on the surface of the tongue. Humans can distinguish among five components of taste: sourness, saltiness, sweetness, bitterness, and umami (...
IMPROVEMENT OF FAST DISINTEGRATING TABLETS USING RANITIDINE HCL
The present study was designed towards the design and development of fast disintegrating tablets by direct compression technology using Ranitidine HCl as a model drug. Fast disintegrating tablet of Ranitidine HCl was for...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF LABETALOL HYDROCHLORIDE USING HYDROPHILIC POLYMERS
Labetalol hydrochloride is used in treatment of hypertension. It has a short half life and undergoes extensive first pass metabolism. In the present study, labetalol hydrochloride 100 mg controlled release matrices were...
Tracheo-esophageal Fistula with VACTREL Anomaly: An Anaesthetic Challenge
Tracheoesophageal fistula (TOF) and associated esophageal atresia (EA) in the neonate, presents during the first week of life. This congenital defect can be complicated by aspiration, respiratory distress, and other cong...