Analiza izobolograficzna ototoksycznych interakcji pomiędzy gentamycyną i furosemidem u myszy — doniesienie wstępne
Journal Title: Otolaryngologia Polska - Year 2011, Vol 65, Issue 3
Abstract
SUMMARY Aminoglycoside antibiotics and loop diuretics have long been known to have ototoxic effects. However, characteristics of pharmacodynamic interactions of these drugs are stil) not recognized. In the presented study, the isobolographic analysis was used, which is an experimental, mathematical-statistical model of evaluation of pharmacological interactions between drugs, given in different fixed and definite combinations. Gentamicin in a dose of 400 mg/kg, furosemide in a dose of 100 mg/kg and their combination at the fixed-ratio of 1:1 were injected intraperitoneally to Albino Swiss mice. Auditory brainstem responses were used to assess the hearing threshold at 15 and 30 min after the drug injections. The combination of gentamicin with furosemide resulted in synergistic interaction. Results of presented work prove that the isobolo-graphic analysis is very precious and usefull to estimate types of interaction of ototoxic drugs. It gives new possibilities in the recognition of mechanisms of action of ototoxic drugs and in prevention of ototoxicity.
Authors and Affiliations
Marek Zadrożniak, Marcin Szymański, Kamal Morshed, Henryk Siwiec, Janusz Klatka, Jarogniew Łuszczki
Keywords
Related Articles
- EP ID EP52286
- DOI -
- Views 119
- Downloads 0
Respiratory papillomatosis – new methods of treatment
Background: Respiratory papillomatosis is caused by HPV. The most common location in head and neck is larynx, palatine tonsils and arches of palate, uvula and mucosa oral and nasal cavity. The disease is benign but recur...
Polysomnographic evaluation of sleep apnea in patients with unilateral or bilateral impaired nasal patency
Introduction. The aim of this work was to describe the polysomnographic evaluation of sleep apnea in patients suffering from unilateral or bilateral impaired nasal passage patency. Material and methods. The study covered...
Wyniki leczenia gruczolaka jednopostaciowego płata powierzchownego ślinianki przyusznej
Wstęp Guz Warthina jest niezłośliwym nowotworem występującym w dużych gruczołach ślinowych. Diagnostyka obejmuje badanie podmiotowe, przedmiotowe oraz badania dodatkowe - ultrasonografię, badanie tomografii rezonansu mag...
Selected applications of diode laser in laryngological surgery
Diode laser due to emitted wavelength and achieved tissue effect appear to be universal tool for broad range of applications in laryngological surgery. The aim of the study was to present variety of applications of this...
Ocena kieszonek retrakcyjnych i sposoby postępowania terapeutycznego
Niniejsza publikacja ma na celu dokonanie przeglądu typów kieszonek retrakcyjnych u dorosłych i dzieci, patogene¬zy ich powstawania, powiązanych czynników ryzyka oraz potencjalnych metod ich zapobiegania i leczenia. Znac...