Analyses of Genomic Changes in Chromosome 17 And P53 Gene In Oral Squamous Cell Carcinoma Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Oral squamous cell carcinoma (OSCC) is widely recognized as the most common type of head and neck cancer and is an important cause of death and morbidity . In Indian population, the situation is more alarming since nearly 10% of the cancers that develop annually belongs to this category. Deactivation and unregulated expression of oncogenes and tumor suppressor genes may be involved in the pathogenesis of oral squamous cell carcinoma. The genomic change results in numerical aberrations in chromosomes 17 & p53 gene. The aim of our study was to identify numerical aberrations of chromosome 17, deletion or amplification of p53 gene. This study was performed retrospectively on 30 cases diagnosed with OSCC through FISH technique. Molecular cytogenetic techniques, using fluorescence in situ hybridization with chromosome-specific DNA probes, facilitate the confirmation of presumed chromosomal aberrations with high sensitivity and specificity. Out of 30 cases 29 represent molecular alteration . About 70 % of cases presented chromosome 17 polysomy and only 20% of cases had chromosome 17 monosomy. 58% of samples revealed p53 gene amplification and 37% of them p53 deletion. High frequency of correlation between molecular changes in chromosome 17 and p53 gene with OSCC indicates towards their critical role in development of this disease.
Authors and Affiliations
Dr. Garima Khatri, Dr. Mohan Singh, Dr. P. M. Sareen, Dr. Mitali Jain, Khushboo Joshi
Keywords
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