ANALYSIS OF EFFECT OF THE ANTIDEPRESSANT SERTALINE ON THE LEGHT OF QT INTERVAL IN PATIENTS WITH DEPRESSION AND ALCOHOL DEPENDENCE
Journal Title: SANAMED - Year 2019, Vol 14, Issue 1
Abstract
Introduction and Aim: Depression in psychiatry covers a large area of mental pathology and it is one of the most complex problems of modern medicine with broad implications for the health of the individual and the society as a whole. Depression is also a frequent companion of alcohol addiction. The aim of this study was to investigate the effect of the antidepressant drug sertaline on the lenght of QT interval in depressed patients with alcohol dependence. Patients and methods: This research included male patients (older than 18 years of age) suffering from alcohol addiction, who were also diagnosed with depression, that is, depressive disorder,at the beginnig of hospitalisation, on the basis of DSM-IV (Diagnostic and statistical manual of mental disorders) criterion and positive Hamilton Rating Scale for Depression (HRSD). The study included 49 patients treated wit antidepressant sertaline for 20 days. In our study, the global QTc interval (12 leads) was determined automatically by applying ECG device of the producer and type "Schiller Cardiovit AT-1"which uses "SCHILLER ECG Measurement and Interpretation Software for Children and Adults ECGs". Measured empirical values of data were statistically processed in SPSS 16.0 programme package for Windows. Methods of descriptive statistics and methods of statistic testing of hypotheses were used. Results: In our study, in spite of the vulnerability of patients due to the heart damage and the lyver dysfunction arising from alcohol consumption, as well as altered patients drugs metabolism, no elongation of QTc interval resulting from the application of sertaline was established (p=0.735). The average prolongation of QTc interval of 1.633 ms was observed (95% CI =8.005 ms, 11.270 ms). Conclusion:Our study does not indicate that the antidepressant drug sertaline has a statistically significant effect on the prolongation of the QT interval of depressed patients with alcohol dependence.
Authors and Affiliations
Sanja Vukadinovic Stojanovic, Zlatan Stojanovic, Gordana Macanovic, Nada Banjac, Zelimir Eric
Keywords
Related Articles
- EP ID EP629860
- DOI 10.24125/sanamed.v14i1.301
- Views 100
- Downloads 0
THE INFLUENCE OF CHRONIC STRESS ON HEALTH AND COPING MECHANISMS
Stress represents a negative life experience, closely followed by physiological, cognitive, emotional, and behavioral changes that focus on changing the event or adapting to its effects. Any situation or occurrence that...
OXYGEN SATURATION INDEX FOR ASSESSMENT OF RESPIRATORY FAILURE IN NEONATES
Introduction: Acute respiratory failure (ARF) is the most common problem seen in the preterm and term infants admitted to neonatal intensive care units. Etiology is not uniform, and mostly depend on gestational age. For...
DOES BEATING HEART SURGERY TECHNIQUE REDUCE THE MORTALITY AND MORBIDITY AFTER REDO VALVE OPERATIONS?
Aim: The aim of this study was to determine the effect of beating heart technique on mortality and morbidity after redo valve operations. Material and Method: Fifty-two patients who had redo open-heart surgery between M...
BIBLIOGRAPHY OF SANAMED JOURNAL (2014-2017)
This paper presents a bibliography of Sanamed, journal of medical and health science, founded by a group of doctors from Novi Pazar. The Journal published original articles, case reports, literature reviews, articles on...
SEVERE PNEUMONIA CAUSED BY ANTIPSIHOTIC DRUGS-WHAT DOES NOT SUIT, THE PATIENT OR THE DRUG?
Introduction: Antipsychotic drugs are generally categorized as typical antipsychotics (sometimes referred to as first-generation or conventional antipsychotics, or neuroleptics) and atypical antipsychotics; both are appr...