Analytical method development and validation of diloxanide furoate and ornidazole in its combined pharmaceutical dosage form
Journal Title: Scholars Academic Journal of Pharmacy - Year 2015, Vol 4, Issue 9
Abstract
A simple, rapid, economical, precise and accurate Stability indicating RP-HPLC method for simultaneous estimation of Diloxanide Furoate and Ornidazole in Their Combined Dosage Form has been developed. The separation was achieved by LC- 20 AT C18 (250mm x 4.6 mm x 2.6 μm) column and Buffer (pH 4.5): Acetonitrile (40:60) as mobile phase, at a flow rate of 1 ml/min. Detection was carried out at 277 nm. Retention time of Ornidazole and Diloxanide Furoate were found to be 4.620 min and 7.633 min, respectively. The method has been validated for linearity, accuracy and precision. Linearity observed for Ornidazole 5-15 μg/ml and for Diloxanide Furoate 7.5-22.5 μg/ml. The percentage recoveries obtained for Ornidazole and Diloxanide Furoate were found to be in range of 100.88 ± 0.60 and 100.85± 0.20 respectively. The proposed method was successfully applied for the simultaneous estimation of both the drugs in commercial combined dosage form
Authors and Affiliations
Hemangi Vaidya, Sweetu Patel, Divya Patel, Prasanna K Pradhan, Umesh Upadhyay
Keywords
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