ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF METAXALONE IN BULK AND ITS PHARMACEUTICAL FORMULATION BY UV SPECTROSCOPIC METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3
Abstract
Metaxalone, a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains and othermusculoskeletal conditions. A simple, accurate, precise, reproducible, highly sensitive, economic UV spectrophotometric method has been developed for the estimation of metaxalon in bulk and tablet dosage form. In this method metaxalon showed maximum absorbance at 280 nm in methanol. The developed spectrophotometric method was validated in accordance with ICH guidelines. Linearity of the method was found to be 5 - 160µg/ml. The method obeyed Beer’s law in the concentration range of 5 -160 µg/ml. The LOD and LOQ were found to be 3.489μg/ml and 10.575μg/ml respectively. A mean recovery of metaxalon in tablet dosage form was found to be 99.69%.the method was found to be simple, accurate, precise, specific, sensitive, reproducible and can be directly and easily applied to tablet dosage form.
Authors and Affiliations
N. V. Reddy, B. Ishaq, V. S. Rajan, C. Gopinath
Keywords
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- EP ID EP141003
- DOI 10.7897/2230-8407.04329
- Views 79
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