Analytical Study for the Charge-Transfer Complexes of Risperidone in Pure and Dosage Forms
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 8, Issue 3
Abstract
Two simple, accurate and sensitive spectrophotometric methods were carried out to investigate through charge-transfer reactions of risperidone (RIS) as n-electron donor with various π acceptors: 7, 7, 8, 8-tetracyanoquinodimethane (TCNQ) and p-chloranilic acid (pCA). The absorbance of reaction product was measured at 842 and 520 nm for TCNQ and pCA reagents respectively. Different experimental parameters affecting the reactions were carefully studied. The reaction pathway was postulated. The proposed spectrophotometric method was utilized for the analysis of RIS in pure form as well as in its pharmaceutical preparations. Under the optimum reaction conditions, Beer’s law is obeyed over the concentration range of 1-12 µg mL-1 and 10-180 µg mL-1 for TCNQ and pCA respectively. The limit of assays detection (LOD) is 0.114 µg mL-1 and 2.55 µg mL-1 for TCNQ and pCA respectively. The mean recovery percentage was 99.72 ± 1.06 and 100.50 ± 1.07 for TCNQ and pCA respectively. The results were compared favorably with those obtained by comparison method. The proposed method was validated statistically according to ICH guidelines.
Authors and Affiliations
F. Ibrahim, N. El-Enany, Sh. Shalan, Rasha Mostafa Elsharawy
Keywords
Related Articles
- EP ID EP652681
- DOI 10.24297/jac.v8i3.4055
- Views 194
- Downloads 0
Azo-Hydrazone Tautomerism and Antimicrobial activity of New substituted Imidazolines and Perimidines
Two new series of 2-{1-[(substitutedphenyl)-hydrazono]-2-oxo-2-phenyl-ethyl}-5,5-diphenyl-3,5-dihydro-imidazol-4-one  and (1H-Perimidin-2-yl)-[(substitutedphenyl)-hydrazono]-acetic acid ethyl ester were prepared by co...
Synthesis and physico-chemical studies of a novel bis [3,5-diamino-4H-1,2,4-triazol-1-ium] dichloride monohydrate
The title new compound, (C2H6N5+)2, 2Cl−.H2O, contains two 3,5-diamino-4H-1,2,4-triazol-1-ium cations, two chloride anions and one water molecule. The crystal structure is stabilized by O - H···Cl, N - H···Cl, N...
Scope of Non-estrogenic Steroidal Congeners against Breast Cancer
Various novel non-estrogenic steroidal D-ring substituted analogs were synthesized and evaluated for their breast cancer activity against human breast cancer cell lines. The good cytotoxic results obtained against the br...
The present status and prospect of research on the de-ironing and bleaching technology of kaolin
The increase of degree of whiteness is an important method for Kaolin growth in value. In this paper, the occurrence of iron in kaolin was briefly described, and the methods of the de-ironing and bleaching technology of...
Aspartic Acid as Corrosion Inhibitor of Mild Steel Corrosion Using Weight Loss, Acidimetry and EIS Measurement
Corrosion inhibition characteristics of aspartic acid on mild steel corrosion in 0.5 M H2SO4 was investigated using weight loss, acidimetry, and electrochemical impedance spectroscopy (EIS). Analysis of the metal s...