Analyzing renal involvement in 100 cases of hematological malignancy
Journal Title: International Journal of Medical Science and Public Health - Year 2015, Vol 4, Issue 4
Abstract
Background: Hematological malignancies are the most common nonrenal neoplasms affecting the kidneys. The incidence and type of renal involvement in these malignancies are variable and differ according to malignancy. Objective: To study the prevalence of renal involvement in hematological malignancies and to study the clinical profile of patients in various malignancies. Materials and Methods: A total of 100 consecutive patients of hematological malignancies (leukemia, lymphoma, and multiple myeloma) were prospectively studied for renal involvement and clinical profile. Results: There were 72 men and 28 women with mean age of 46.85 ± 19.23 years. Among them, 43% patients had leukemia, 33% patients had lymphoma, and 24% patients had multiple myeloma. Renal failure was present in 37% of the total patients and one-third patients were having azotemic symptoms at presentation. Mean blood urea and serum creatinine levels were 73.75 ± 77.49 and 2.42 ± 3.22 mg/dl, respectively. Mean glomerular filtration rate (GFR) was 71.29 ± 54.92 ml/min and 17% patients had GFR < 15 ml/min; 62.5% patients of multiple myeloma had renal failure. Four patients had acute urate nephropathy (three patients had acute leukemia and one patient had multiple myeloma). Of the total, 18% patients had hypercalcemia and 41.7% patients had myeloma. Hyperuricemia was observed in 55.5% patients. Tumor lysis syndrome was seen in three patients and all these patients were having multiple myeloma. Male sex, multiple myeloma, and hyperuricemia were significant factors contributing to renal failure ( p < 0.05). Conclusion: All patients with hematological malignancies should be evaluated for renal dysfunction and all preventive measures should be used in these patients, especially when initiated on chemotherapy.
Authors and Affiliations
Vikas Makkar, Sandeep Puri, Sahil Mehta, Amit Bery, JS Sandhu, JS Sekhon
Keywords
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- EP ID EP158834
- DOI http://dx.doi.org/10.5455/ijmsph.2015.06122014103
- Views 57
- Downloads 0
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