Anesthetic Considerations of a Surgical Patient with Favism: A Case Report
Journal Title: Journal of Blood Disorders & Transfusion - Year 2018, Vol 9, Issue 2
Abstract
Rationale: Favism is a genetic disease of Glucose 6 phosphatase dehydrogenase (G6PD) deficiency in humanred blood cells. It is mainly due to the mutation of G6PD gene encoded on the X chromosome, which leads to thedecrease of G6PD activity or deficiency. G6PD plays important roles in the metabolic process of human body. Oneof them is to protect the integrity of the erythrocyte membrane. When the body is lack of G6PD or its activity isreduced, the patient is prone to hemolysis after eating oxidant, such as fresh broad bean, or under strong stress.Patient concerns and diagnoses: A 43 year old male patient diagnosed with lumbar intervertebral discherniation was hospitalized and planned for a surgery of the lumbar spine under general anesthesia. The patientwas diagnosed as favism at an early age, but in later growth and life there was no hemolysis due to the doctor'sinstructions.Anesthesia: We chose total intravenous anesthesia and avoided some drugs which may induce hemolysis.During the operation, we monitored the heart rate, blood pressure, blood gas and urine indicators to determinewhether the patient had hemolysis and actively deal with it.Result: During the process, the patients' circulation and respiration was stable, the operation was smooth, andwe followed up him the first-third 7th day after the surgery. The patients recovered well and had no acute hemolyticreaction. It can be seen that our treatment may provide some experience for postoperative anaesthesia of patientswith broad bean disease
Authors and Affiliations
Xiaoli Wang, Yuanjun Qing, Tao Hu, Peilin Cong, Qingxiu Wang
Keywords
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- EP ID EP582745
- DOI 10.4172/2155-9864.1000403
- Views 123
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