Angiotensin Converting Enzyme Gene Polymorphism And Hypertension In North Coastal Andhra Pradesh, India
Journal Title: International Journal of Medical and Health Sciences - Year 2013, Vol 2, Issue 1
Abstract
Background: The angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism has been identified as a potential genetic risk factor for essential hypertension. The angiotensin-converting enzyme in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different diseases. In this study we aimed to investigate the I/D genotype frequency in hypertensive cases in north coastal Andhra Pradesh, India . The purpose of the present study is to investigate the association of the insertion/deletion polymorphism of the ACE gene with essential hypertension in patients of north coastal Andhra Pradesh . Materials and Methods: We designed a case control study, where 100 hypertensive cases were studied for ACE I/D polymorphism against 100 age and sex matched controls taken from the general population. The polymorphisms of Angiotensine Converting Enzyme gene were investigated using polymerase chain reaction for detection of I/D genotype. Fishers Chi square test was used for calculation of P value and odds ratio (OR). Results: We found the frequency of DD genotype to be 46.0% (46/100), ID 29.0% (29/100) and II 25.0% (25/100) in 100 hypertensive cases. Subjects having D allele have 35 times more risk of complication than I allele (odds ratio: 7.12; CI: 3.5-14.2; 2=35.94, P < 0.0000001). Conclusions: The ACE I/D genotype is positively associated with hypertension in our population. Moreover, individuals who are homozygous for the D allele of the ACE gene are more likely to have essential hypertension and its complications. KEYWORDS: ACE, I/D Polymorphism, hypertension.
Authors and Affiliations
Nirupama Devi, V. Lakshmi, Karunakara Padhy, Rashmita Padhy, P. Veerraju
Keywords
Related Articles
- EP ID EP39690
- DOI -
- Views 266
- Downloads 0
Atopic disorders in school children in Indonesia: A study on characteristics and Helminth infections
Background: Atopy predisposes the marked onset of allergic reaction in vast number of IgE response in the peripheral vessels. IgE is increased in patients with atopy, asthma, atopic dermatitis and helminth infections. T...
Left Congenital Diaphragmatic Hernia: A Case Report
Congenital diaphragmatic hernia occurs when the diaphragm fails to fuse properly during fetal development, allowing the abdominal organs to move up into the chest cavity. The diagnosis can be made in the prenatal period...
Correlative study of intraocular pressure and body mass index in North Indian subjects
Background: Various systemic and local factors affect IOP. Raised IOP is the major risk factor for development and progression of glaucoma. BMI is a modifiable systemic factor which can affect IOP. Aim: To find the corr...
Colonic Angiolipoma Presenting As Intussusception: A Rare Case Report
Angiolipoma & lipomas are frequently observed benign neoplasms that are often located in the subcutaneous tissue but can rarely arise in the gastrointestinal tract. These tumors are usually asymptomatic but may present...
Running Speed and Agility according to Bruininks Oseretsky Test of Motor Proficiency, 2nd edition
Introduction: Evaluation of running speed and agility in school going children of age 5 to 15 years. Running speed and agility (RSA) is essential in children like other factors like strength, endurance and power. The pu...