ANTI-ANAEMIC ACTIVITY OF HYDRO-ALCOHOLIC LEAF EXTRACT OF LUFFA AEGYPTIACA IN PHENYLHYDRAZINE INDUCED ANEMIC RATS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
The main aim of the current study is to determine the anti-anaemic activity in hydro-alcoholic leaf extract of Luffa aegyptiaca in phenylhydrazine induced anemic rats. Phenylhydrazine (60mg/kg) was administered intraperitoneally in rats for 2 days to induce anemia. The animals were divided into 5 groups containing 6 animals each. 1st group was served as normal control group, 2nd group was served as anaemic control administered with phenylhydrazine for two days, 3rd group was served as standard reference control administered with Vitamin B12 complex, 4th group was served as test control administered with 100 mg/kg of hydro-alcoholic leaf extract of Luffa aegyptiaca and 5th group was served as test control administered with 200mg/kg of hydro-alcoholic leaf extract of Luffa aegyptica. All the test drugs were given for 28 days daily through oral route. On 29th day blood was withdrawn, through tail puncture and subjected to the determination of RBC, Hb and percentage Haematocrit. Both the hydro-alcoholic leaf extract of Luffa aegyptiacaand Vit. B12 significantly increase the HB, RBC & % HCT level which indicates that Luffa aegyptiaca leaf exhibits’ the anti-anaemic activity.
Authors and Affiliations
Deepanshu Gupta
Keywords
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