Anti-Angiogenic Effect of Caryota Urens Fruits Extract on the Fin of Zebrafish
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
The aim of this study is to explore Caryota urens which may lead to discovery of new therapeutic agents which may inhibit process of angiogenesis and in future which may be utilized for treatment of various disease condition like cancer, cardiovascular diseases, arthritis, diabetic retinopathy etc. where angiogenesis play a major role in modulating disease processes. With this aim, the objectives of the study includes identification of active constituent which will be crucial in understanding the mechanism of action of the said activities and to evaluate the anti-angiogenic activity of the Caryota urens fruit extract in zebra fish fin regeneration model. Zebra fishes were maintained and fish regeneration assay was done on ethanolic extract of Caryota urens (EECU) and inhibition in regeneration of zebra fish fin was observed for over a period of thirty days with regular dosing on every alternate day. Fishes were divided into groups. The groups were treated with various concentrations of test and standard drug. Area of regenerated fin was measured frequently by observation under microscope and measurement by softwares. The dose response of test and standard were plotted and inhibition in regeneration was observed accordingly. The inhibition of regeneration of fin in zebra fish was observed in test drug which may be as a result of phytoconstituents present in Caryota urens. The present study represents that the zebra fish models can be applied for studying anti-angiogenic activity and Caryota urens have potential for further exploring for its application in inhibition of process of angiogenesis
Authors and Affiliations
Vikram Shokin Bafna
Keywords
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