Anti arthritic potentials of Piper betle- A preclinical study
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 1
Abstract
The objective of the recent work was to evaluate the antiarthritic activity of Piper betle leaves against CFA induced arthritis in rats Antiarthritic activity of hydroalcoholic 14 extract of Piper betle leaves was investigated against complete Freundrsquos adjuvant induced arthritis in rats Two doses 20A0mgkg and 400mgkg of Piper betle leaves extract oral route was subjected for the evaluation of antiarthritic activity against complete Freundrsquos adjuvant 01ml sub plantar region induced arthritis in rats Diclofenac 50mgkg oral was used as standard in both the models prophylactic amp curative Physical parameters such as paw volume paw diameter and body weight were evaluated Serum parameters such as SGPT SGOT and ALP rheumatoid factor were evaluated In addition histopathological study was also carried out It was observed in both the models that both the lower dose 200mgkg and higher dose 400mgkg of Piper betle extract showed dose dependent significant decrease in SGPT SGOT and ALP paw volume paw diameter and increase in body weight when compared to arthritic control group All treated animals showed significant decrease in serum rheumatoid factor In addition antiarthritic effect was also confirmed by histopathology of synovial joint showed less space narrowing of inter tarsal joints in treated rats The results obtained were comparable with that of standard The present study concluded that hydroalcoholic extract of Piper betle leaves has significant antiarthritic potential The exact mechanism for the antiarthritic activity of hydroalcoholic extract of Piper betle is still unknown Hence further studies are needed to isolate characterize the active principles and to find out the exact mechanism responsible for its antiarthritic activityKeywords Arthritis Complete Freundrsquos Adjuvant Diclofenac Piper betle Rheumatoid factor
Authors and Affiliations
Karunakar Hegde, Aparna Emani, Shrijani J K, A R Shabaraya
Keywords
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- EP ID EP478533
- DOI 10.18231/2393-9087.2018.0006
- Views 94
- Downloads 0
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