Anti-C1q Antibody is Associated with Renal and Cutaneous Manifestations in Asian Indian Patients with Systemic Lupus Erythematosus
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 3
Abstract
Introduction: C1q play an important role in clearance of immune complexes and apoptotic cell debris. Impaired clearance leads to exposure of C1 native antigen and development of antiC1q antibody formation. Anti-C1q antibody is well studied in Systemic Lupus Erythematosus (SLE). Significance of anti-C1q Ab in Indian SLE patients and their clinical manifestations is not clear. Aim: The aim of this study was to investigate associations between anti-C1q antibody and clinical as well as serological markers of SLE. Materials and Methods: Retrospective study of SLE patients fulfilling either American College of Rheumatology (ACR) 1990 or Systemic Lupus International Collaborating Clinics (SLICC) 2012 classification criteria were recruited from inpatients and outpatients services of the Clinical immunology and Rheumatology Department, Christian Medical College at Vellore, India between March 2013 and January 2015. AntiC1q antibody was assayed by ELISA (Demeditec Diagnostics GmbH, Germany). Logistic regression analysis was performed to find the association of anti-C1q antibodies with serological and clinical parameters in SLE including Lupus Nephritis (LN). Results: Sixty nine patients (54.76%) out of 126 SLE patients had LN. Anti-C1q levels were higher in patients with LN as compared to those without (p<0.05). Anti-C1q antibody was also significantly associated with positive C1q immunofluorescence staining in renal biopsy specimens (p<0.05). Overall, renal Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) {OR 1.35 (1.08-1.69)}, low C4 {OR 3.11 (1.04-9.26)} and mucocutaneous manifestation {OR 4.72 (1.38-16.05)} were independently associated with anti-C1q levels in serum. Conclusion: Renal SLEDAI, low C4 and mucocutaneous manifestations were independently associated with raised anti C1q antibody in SLE patients.
Authors and Affiliations
Jayakanthan Kabeerdos, Nikhil Gupta, Sandhya Pulukool, Hindhumathi Mohan, Gowri Mahasampath, Debashish Danda
Keywords
Related Articles
- EP ID EP335462
- DOI 10.7860/JCDR/2017/22661.9545
- Views 98
- Downloads 0
Factors Associated with Low Muscle Tone and Impact of Common Musculoskeletal Problems on Motor Development in Preterm Infants at One Year of Corrected Age
ABSTRACT Introduction: Structural immaturity of muscular system in Preterm Infants (PTI) results in maturation related hypotonia which is found to be influenced by risk factors present at the time of birth. Low muscle to...
Dental Students’ Perception of Dentine Hypersensitivity and Awareness about its Management
ABSTRACT Introduction: Dentine hypersensitivity is a common painful oral condition that can interfere with drinking, eating, tooth brushing and even breathing. Successful management depends on the identification and elim...
Radio-Diagnostic Dilemmas of Submandibular Calcification-An Incidental CBCT Finding
ABSTRACT Heterotrophic Calcifications (HC’s) are often encountered as incidental findings in dental radiographic examinations. Inexperienced clinicians may misdiagnose these tame calcifications and levy unnecessary treat...
Juvenile Nasopharyngeal Angiofibroma: A Case Report
Juvenile nasopharyngeal angiofibroma is tumour almost exclusively seen in adolescent males, constituting less than 1% of all neoplasms in head and neck. They are benign and locally spreading and are highly vascular in na...
Comment on “Serological Evidence of Scrub Typhus among Cases of PUO in the Kashmir Valley- A Hospital Based Study”
Letter to Editor