Anti-Genetic Exceptionalism in Complex Disorders: Making a Case for Disclosure of Polymorphic Genetic Results in Clinical Research Studies
Journal Title: Journal of Neurology and Psychology - Year 2013, Vol 1, Issue 2
Abstract
It is increasingly common for clinical research studies to include a genetic component. In complex genetic disorders, disease is associated with variation in many genes, each of which contributes only a small, discrete effect. The nature of the genetic information generated by such studies increasingly necessitates re-examination of the ethical precepts underlying their research questions, study designs, and disclosure practices. This article addresses the ethical basis for decisions whether to disclose the results of testing for polymorphic genetic variation to individual research participants, who often express great interest in knowing “Do I have the gene?” The paper argues that information about polymorphic genetic variation is unexceptional when compared to other data commonly collected in clinical research studies, such as age, blood pressure readings, or family history. This lack of exceptionalism should be considered in the procedures for disclosure in research studies of complex disorders involving polymorphic genetic variation.
Authors and Affiliations
Amy E. Sanders
Keywords
Related Articles
- EP ID EP195123
- DOI 10.13188/2332-3469.1000005
- Views 106
- Downloads 0
What is the function of the Brain? What does it do and how does it do it? It functions as a Neuroregulator, which continuously regulates the Autonomic Nervous System and Physiological Systems, and enables us to Recognise that Sleep Exhibits the Characteristics of a Neurally Regulated Physiological System
The aim of this article is to provoke further discussion of the mechanisms which the brain uses to regulate the body´s function, in particular the autonomic nervous system. It focuses upon an understanding of the structu...
Effect of Helicobacter pylori Eradication on Migraine Headache: A Before -After Clinical Trial
Background: Migraine is the most frequent type of primary headache. It has been demonstrated that H. pylori infection eradication has a possible role in the reduction of migraine headache but needs to be examined in diff...
Implementing Implementation Science: Reviewing the Quest to Develop Methods and Frameworks for Effective Implementation
How to tackle the implementation of Implementation Science is the theme of this discussion. For many of us, Implementation Science itself may need some introduction. Implementation Science is an emerging science explorin...
Interpersonal Psychotherapy Efficacy in Different Clinical Settings
Interpersonal therapy is an effective brief and limited therapy originally developed for major depression disorder but nowadays also highly effective in other psychiatric disorders [1,2]. This therapy uses the biopsychos...
Differences in the Lipid Domain Organization of Erythrocyte Membranes in Patients with Schizophrenia
Gradually accumulating evidence indicates that schizophrenia may be accompanied by alterations of membrane phospholipids, however knowledge about how it affects lipid domain organization of membrane is lacking. We compar...