Anti-inflammatory Activity of Matricaria recutita L. against Acute and Chronic Inflammatory Models
Journal Title: STAR Journal - Year 2014, Vol 3, Issue 1
Abstract
Chamomile (Matricaria recutita L.) is most popular used medicinal plant and extensively consumed as a tea and food. We investigated the effects of Matricaria recutita L. (MR) in acute and chronic inflammatory conditions. The anti-inflammatory activity of Matricaria recutita was studied against carrageenan induced hind paw, arachidonic acid, acetic acid and complete Freund’s adjuvant (CFA)-induced arthritis in rats. The methanol extract of Matricaria recutita was administered at the dose of 100, 200 and 300 mg/kg body weight. In CFA-induced model ESR, vascular permeability, histamine release from blood and biochemical parameters were carried out. Chamomile methanol extract showed dose dependent significant (P<0.001) anti-inflammatory activity by inhibition of rat paw oedema against carrageenan and arachidonic acid and inhibition of writhing induced by acetic acid. The significant anti-arthritic activity was observed with administration of Chamomile extract in the Freund’s adjuvant induced model of arthritis. Chronic treatment of extract of Chamomile showed significant decrease the development of arthritis and reduced ESR observed. It also reduced the histamine release from blood and vascular permeability at joint. The methanol extract of Matricaria recutita possess potential anti-inflammatory activity against acute and chronic inflammatory model.
Authors and Affiliations
Katti HR| Department of Orthopedics, S. Nijalingappa Medical College and Research Centre, Bagalkot-587101, Karnataka, India, Ramkishan A| Department of Pharmacology, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Campus, Bagalkot-587101, Karnataka, India, Ramkishan A| Central Drugs Standard Control Organization, Subzonal office, Airport, Ahmedabad-380015, Gujarat, Chandrashekhar VM| Department of Pharmacology, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Campus, Bagalkot-587101, Karnataka, India, Sowmya C| Department of Pharmacology, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Campus, Bagalkot-587101, Karnataka, India, PanjiM A| Department of Pharmacology, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Campus, Bagalkot-587101, Karnataka, India
Keywords
Related Articles
- EP ID EP9617
- DOI http://dx.doi.org/10.4314/star.v3i1.1
- Views 396
- Downloads 18
Study of Production Practices, and Productivity of Village Chicken in Chelliya District, Ethiopia
No Abstract
Analysis of Adoption Spell of Hybrid Maize in the Central Rift Valley, Oromyia National Regional State of Ethiopia: A Duration Model Approach
This paper estimates farm household level determinants of the speed of adoption of hybrid maize in the central rift valley of Ethiopia in the framework of the dynamic time on crosssectional data. Descriptive statistics...
Schistosoma mansoni Infection in Finchaa Sugar Estate: Public health Problem Assessment based on Clinical Records and Parasitological Surveys, Western Ethiopia
The survey of Schistosoma mansoni (S. mansoni) in Finchaa Sugar Estate, Western Ethiopia, was conducted to investigate the prevalence and health problems of schistosomiasis with some of the risk factors. The examinatio...
The Need for Professional Growth of ELT Teachers in Ethiopia
This paper presents the need for professional growth of English language teachers in Ethiopia. It indicates that English language teachers teach what they know, what they have, what they think, and what they believe. T...
Teachers’ Perceptions and Practices of Active Learning in Haramaya University, Eastern Ethiopia: The Case of Faculty of Education
The purpose of this study was to investigate instructors’ perceptions and practices of active learning, assess the extent to which instructors’ perceptions influence their practices and identify factors affecting t...