ANTI-INFLAMMATORY EFFECT OF LIPID EXTRACT OF SEA PEN (VIRGULARIA GUSTAVIANA) IN MICE
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
 Objective: Sea pens are a highly specialized group of anthozoa coelenterates. Sea pens were collected by wading at low tide in intertidal zone fromBandar Abbas Costal.Method: Sea pens were identified by classification keys, and samples were sending to the academic center of California for admission. Comparingidentification keys genus from virgularidaes family was identified, it consisted of Virgularia gustaviana. To find an effective fraction, the inflammatoryeffect of lipid extract hexane of sea pen V. gustaviana was evaluated. In this study, lipid percentages of V. gustaviana were measured, and the percentageof sterol profile was assessed. To assess inflammation, mouse ear edema method was used. Male NMRI mice were categorized into three groupsincluding positive control (dexamethasone 15 mg/kg), negative control (saline) and experimental one with dose of 10, 20, 40, and 60 mg/kg of lipidextracted of chloroform and hexane as a separate group.Results: Total lipid V. gustaviana was 21.96% and sterol profile which was 5680.31 mg/kg contains cholesterol 1910.38 mg/kg that equal 57.95%of total sterol and brassicasterol, campesterol, campestanol, stigmasterol, beta-sitosterol were measured. Fatty acid profile was measured by gaschromatography-mass and heptadecane 44.25%, beta.-Bisabolene ss Cyclohexene’1, 18.16%, and methyl arachidonate 54.17% was assessed.Statistical analysis was performed that anti-inflammatory effect of all doses of 40-10 mg/kg is significant to the control.Conclusion: Chloroform and hexane extracts of sea pen has a strong anti-inflammatory effects even at low doses which is probably due to 54%arachidonic acid in the compounds.Keywords: Anti-inflammatory activities, Lipid extract, Sea pen (Virgularia gustaviana).
Authors and Affiliations
Sharareh Sharifi, Shila Safaeian
Keywords
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