Anti-inflammatory Effects of Quranic Plants’ Mixture: A New Pharmaceutical Product
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 6, Issue 4
Abstract
Aims: This work was carried out to determine anti-inflammatory effects of this new pharmaceutical product (Quranic Plants’ Mixture) and also to study side effects of this product on many important organs of the body of investigated animals. Place and Duration of the Study: In vivo studies were carried out in the Animal House of the National Research Centre, Dokki, Giza, Egypt (during 21-22 July 2014). Histological studies of investigated animals were done in the Pathology Department Lab, Theodor Bilharz Research Institute, Giza, Egypt. Study Design: Three different doses of this new pharmaceutical product were tested in this study regarding their anti-inflammatory effects. Methodology: In vivo studies of anti-inflammatory effects of feeding adult female albino rats under investigation with three different doses (2, 4 and 8 g/kg ) of this new pharmaceutical product were carried out after 24 hours of inducing inflammation by injecting investigated animals with carrageen. Additionally, weights of many important organs (Brain, Kidney, Liver, Heart, Lung, Spleen, Stomach and Colon) of the body of investigated animals were measured, along with investigations of their histological structures, to examine any bad side effects of this new pharmaceutical product on investigated animals. Results: In vivo studies of anti-inflammatory effects of feeding adult female albino rats under investigation with three different doses (2, 4 and 8 g/kg ) of this new pharmaceutical product showed that, both edema sizes and weights were decreased in case of feeding these rats with all investigated doses of Quranic plants’ mixture. In this regard the highest anti-inflammatory effect was obtained by feeding animals with 8 g/kg of Quranic plants’ mixture based on edema weight estimation; however, 2 g/kg of Quranic plants’ mixture was found to be the best effective dose by estimating edema sizes of inflammated rats. Weights’ estimation and histological investigations of many important organs of the body of investigated animals revealed that, all investigated doses (2, 4 and 8 g/kg ) of Quranic plants’ mixture have not any bad side effects on many important organs of all examined rats. Conclusion: These promising results of anti-inflammatory effects of Quranic plants’ mixture will add a new safe anti-inflammatory agent in the world of pharmaceutical products; also these results will lead us to more biological and chemical investigations of this new, cheap and safe pharmaceutical natural product of plant origin.
Authors and Affiliations
Eman A. Alam
Keywords
Related Articles
- EP ID EP344341
- DOI 10.9734/BJPR/2015/15934
- Views 108
- Downloads 0
In vitro Antimicrobial Activity of Commercially Available Melaleuca alternifolia (Tea Tree) Oil on Some Selected Clinical Pathogens
Aim: To evaluate the In vitro antimicrobial activity of Melaleuca alternifolia oil (tea tree oil), (TTO) on selected clinical isolates of fungi and bacteria, including some multidrug resistant strains commonly associated...
Potential for a Beneficial Effect of Theophylline on Extended Acute Inflammation: Review
Inflammation is often prolonged after sepsis, trauma and other acute pro-inflammatory events, particularly above the age of 80 years. Exposure to inflammation of inappropriate amplitude or duration is associated with a h...
Investigation of Design Principles and Users Demand for Hospital Gardens: Case Study of Egirdir-Turkey
Aims: The plants in hospital garden have many functions to users. Hence attention on those areas should be done. A specific hospital and its gardens chosen to be determine expectations and express of users to determine s...
Characteristics, Complexation and Analytical Methods of Darunavir
What is it? Darunavir is a protease inhibitor used in the treatment of HIV infection. It is an important drug of therapy cocktail for patients infected with the virus. On the market there are darunavir ethanolate tablets...
Human Skin Penetration and Distribution via Different Vesicular Systems
Aims: This Study was performed to evaluate the quantitative distribution of mannitol (model hydrophilic molecule) and corticosterone (model lipophilic molecule) in human skin following the application of different vesicu...