Anti-inflammatory microglial cell function in the light of the latest scientific research
Journal Title: Annales Academiae Medicae Silesiensis - Year 2015, Vol 69, Issue
Abstract
Microglia represent the immune system in the central nervous system. They have long been regarded as as the main aggressor, which induce and support inflammatory and neurodegenerative processes in the central nervous system. The latest studies indicate that they can also play a protective role. In this study we present evidence underlying their anti-inflammatory properties. Microglia can be activated in two different ways and they have two different pheno-types: classical – pro-inflammatory and alternative – anti-inflammatory. The latter is characterized by CD200 ex-pression and fractalkine. Alternatively, the activated microglia also produce pro-inflammatory cytokine. Their influ-ence on the surrounding cells is associated not only with destruction but also with neuroregeneration and myelination. Perhaps the latest reports will draw researchers' attention to new solutions which may be used in the prevention and treatment of the central
Authors and Affiliations
Krzysztof Łabuzek, Edyta Skrudlik, Bożena Gabryel, Bogusław Okopień
Keywords
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