Anti-inflammatory potential of flavonoids from Hemigraphis colorata
Journal Title: International Journal of Life Science - Year 2018, Vol 6, Issue 2
Abstract
Agents that inhibit inflammatory mediators are highly recommended in the development of anti-inflammatory drugs. Flavonoids are large class of secondary metabolites around 10,000 structures, possess anti-inflammatory and various other properties which are valuable to human beings. In this study, different fractions of Hemigraphis colorata were collected based on increasing polarity and quantified the flavonoid content. Anti-inflammatory property was evaluated both in vitro and in vivo method. The chloroform fraction possess highest amount of flavonoid, 6.66 µg/100 µg sample. In the in vitro experiment acetone fraction possess maximum activity. In the in vivo experiment, acetone extract showed 43% and 48% of inhibition at 250 & 500 mg/kg b.wt. respectively against carrageenan induced paw oedema, while standard anti-inflammatory Diclophenac(10mg/Kg) exhibit 52.5 % inhibition
Authors and Affiliations
Shahid Adangampurath, Sudheesh Sudhakaran
Keywords
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