Anti-Neutrophil Cytoplasmic Antibodies In Systemic Lupus Erythematosus And Lupus Nephritis: An Overlapping Syndrome
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Systemic lupus erythematosus (SLE) and small-sized vessel vasculitis are usually two distinguishable autoimmune diseases. However, vasculitis may be found in the course of SLE but rarely corresponds to an antineutrophil cytoplasmatic antibodies (ANCA) associated vasculitis (AAV). We report a case SLE with lupus nepritis (LN) associated with perinuclear (p-ANCA). The frequency of this association seems not fortuitous. Although the etiopathogenic mechanisms of such association remain to be described, several clinical, histological and immunological features support the hypothesis of the existence of SLE-AAV overlapping syndrome. Moreover clinicians must be aware of such overlapping syndrome, notably because its initial presentation can be very severe.
Authors and Affiliations
Tahmina Jesmin, Ranjit Ranjan Roy, Md. Firoz Anjum, Muslima Akter
Keywords
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- EP ID EP595492
- DOI 10.9790/0853-1603050608
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